Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model

Zhanfei Li; Huibing Liu; Zhengxing He; Guorui Zhang; Jinghe Lang

doi:10.1016/j.ejps.2016.07.018

Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model

Zhanfei Li, Huibing Liu, Zhengxing He, Guorui Zhang, Jinghe Lang

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2016 · vol. 93 , pp. 132–140 · doi:10.1016/j.ejps.2016.07.018 · PMID:27481456 · W2481572639

article OA: closed CC0 ⤵ 9 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the effects of cisplatin and letrozole on surgically induced endometriosis in a rat model, comparing their efficacy in treating the condition.

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Condition tags

endometriosis

MeSH descriptors

Cisplatin Disease Models, Animal Endometriosis Nitriles Triazoles Animals Cisplatin Endometriosis Endometriosis Female Letrozole Nitriles Rats Triazoles

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References (66)

Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis via openalex
Aromatase in endometriosis and uterine leiomyomata via openalex
Aromatase inhibitors for the treatment of endometriosis via openalex
Aromatase inhibitors in post-menopausal endometriosis via openalex
Aromatase inhibitors in the treatment of endometriosis via openalex
Aromatase Inhibitors in the Treatment of Severe Endometriosis via openalex
Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer via openalex
Clear cell carcinoma arising from a uterus‐like mass via openalex
Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model via openalex
Dendritic Cells Attenuate the Early Establishment of Endometriosis-Like Lesions in a Murine Model via openalex
Developing a Noninvasive Procedure Using Labeled Monoclonal Antibody Anti-VEGF (Bevacizumab) for Detection of Endometriosis via openalex
Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis via openalex
Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis via openalex
Effects of Pazopanib, Sunitinib, and Sorafenib, Anti-VEGF Agents, on the Growth of Experimental Endometriosis in Rats via openalex
Endometrioid adenocarcinoma with squamous differentiation arising from ureteral endometriosis in a patient with no history of gonadal endometriosis via openalex
Endometrioid carcinoma of the sigmoid colon via openalex
Endometriosis: novel etiopathogenetic concepts and clinical perspectives via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum via openalex
Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis via openalex
Expression of transforming growth factor β1 in nerve fibers is related to dysmenorrhea and laparoscopic appearance of endometriotic implants via openalex
Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis via openalex
Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis: a randomized trial with a 6-year follow-up via openalex
Matrix Metalloproteinases and Endometriosis via openalex
Ovarian carcinoma associated with endometriosis via openalex
Pathogenesis of endometriosis via openalex
Pathogenesis of Endometriosis via openalex
Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development via openalex
Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex
Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex
Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis via openalex
Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis via openalex
Postmenopausal endometriosis via openalex
[Present and future of basic studies on endometriosis]. via openalex
Present and future of basic studies on endometriosis via openalex
Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients via openalex
Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up*1 via openalex
Role of vascular endothelial growth factor polymorphisms (-2578C > A, -460 T > C, -1154G > A, +405G > C and +936C > T) in endometriosis: a case–control study with Brazilians via openalex
Size and spatial orientation of uterine tissue transplants on the peritoneum crucially determine the growth and cyst formation of endometriosis-like lesions in mice via openalex
Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis via openalex
The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study via openalex
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex
The emerging use of aromatase inhibitors for endometriosis treatment via openalex
Theories on the Pathogenesis of Endometriosis via openalex
Therapeutic efficiency of Atosiban, an oxytocin receptor blocking agent in the treatment of experimental endometriosis via openalex
Using Rats as a Research Model for the Study of Endometriosis via openalex
Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum via openalex
W2155024696 via openalex
W2160900629 via openalex
W2067202752 via openalex
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W2097573529 via openalex
W2117413404 via openalex
W2006091414 via openalex
W1971586374 via openalex
W1971554980 via openalex
W1725497901 via openalex
W1495287184 via openalex
W107188628 via openalex
W6604355421 via openalex
W6669536945 via openalex
W6672127118 via openalex
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W2094889223 via openalex
W6714327511 via openalex
W2079190330 via openalex

Cited by (9)

Source provenance

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License: CC0 · commercial use OK

[1] Aromatase expression in endometriotic tissues and cell cultures of patients with endometriosis via openalex

[2] Aromatase in endometriosis and uterine leiomyomata via openalex

[3] Aromatase inhibitors for the treatment of endometriosis via openalex

[4] Aromatase inhibitors in post-menopausal endometriosis via openalex

[5] Aromatase inhibitors in the treatment of endometriosis via openalex

[6] Aromatase Inhibitors in the Treatment of Severe Endometriosis via openalex

[7] Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer via openalex

[8] Clear cell carcinoma arising from a uterus‐like mass via openalex

[9] Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model via openalex

[10] Dendritic Cells Attenuate the Early Establishment of Endometriosis-Like Lesions in a Murine Model via openalex

[11] Developing a Noninvasive Procedure Using Labeled Monoclonal Antibody Anti-VEGF (Bevacizumab) for Detection of Endometriosis via openalex

[12] Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis via openalex

[13] Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis via openalex

[14] Effects of Pazopanib, Sunitinib, and Sorafenib, Anti-VEGF Agents, on the Growth of Experimental Endometriosis in Rats via openalex

[15] Endometrioid adenocarcinoma with squamous differentiation arising from ureteral endometriosis in a patient with no history of gonadal endometriosis via openalex

[16] Endometrioid carcinoma of the sigmoid colon via openalex

[17] Endometriosis: novel etiopathogenetic concepts and clinical perspectives via openalex

[18] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[19] Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum via openalex

[20] Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis via openalex

[21] Expression of transforming growth factor β1 in nerve fibers is related to dysmenorrhea and laparoscopic appearance of endometriotic implants via openalex

[22] Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis via openalex

[23] Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis: a randomized trial with a 6-year follow-up via openalex

[24] Matrix Metalloproteinases and Endometriosis via openalex

[25] Ovarian carcinoma associated with endometriosis via openalex

[26] Pathogenesis of endometriosis via openalex

[27] Pathogenesis of Endometriosis via openalex

[28] Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development via openalex

[29] Pathogenetic Mechanisms of Deep Infiltrating Endometriosis via openalex

[30] Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex

[31] Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis via openalex

[32] Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis via openalex

[33] Postmenopausal endometriosis via openalex

[34] [Present and future of basic studies on endometriosis]. via openalex

[35] Present and future of basic studies on endometriosis via openalex

[36] Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients via openalex

[37] Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up*1 via openalex

[38] Role of vascular endothelial growth factor polymorphisms (-2578C > A, -460 T > C, -1154G > A, +405G > C and +936C > T) in endometriosis: a case–control study with Brazilians via openalex

[39] Size and spatial orientation of uterine tissue transplants on the peritoneum crucially determine the growth and cyst formation of endometriosis-like lesions in mice via openalex

[40] Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis via openalex

[41] The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study via openalex

[42] The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex

[43] The emerging use of aromatase inhibitors for endometriosis treatment via openalex

[44] Theories on the Pathogenesis of Endometriosis via openalex

[45] Therapeutic efficiency of Atosiban, an oxytocin receptor blocking agent in the treatment of experimental endometriosis via openalex

[46] Using Rats as a Research Model for the Study of Endometriosis via openalex

[47] Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum via openalex

[48] W2155024696 via openalex

[49] W2160900629 via openalex

[50] W2067202752 via openalex

[51] W2016599382 via openalex

[52] W2097573529 via openalex

[53] W2117413404 via openalex

[54] W2006091414 via openalex

[55] W1971586374 via openalex

[56] W1971554980 via openalex

[57] W1725497901 via openalex

[58] W1495287184 via openalex

[59] W107188628 via openalex

[60] W6604355421 via openalex

[61] W6669536945 via openalex

[62] W6672127118 via openalex

[63] W6683661443 via openalex

[64] W2094889223 via openalex

[65] W6714327511 via openalex

[66] W2079190330 via openalex