Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis
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This study investigated the association between polymorphisms in the MMP-2 and MMP-9 promoter regions and endometriosis.
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Abstract
In this case-control study, we investigated the potential associations of MMP-2 and MMP-9 gene promoter region polymorphisms as well as MMP-2 promoter haplotypes with susceptibility to endometriosis in women of caucasian origin. The results demonstrated that polymorphisms in MMP-2 (-735 C/T) and MMP-9 (-1562 C/T) were associated with elevated risk of endometriosis and that certain MMP-2 promoter haplotypes were more common in control group.
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Cited by (32)
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- Features of Matrix Metalloproteinases MMP2, MMP3, and MMP9 of Regulatory-Region Polymorphism in Patients with Uterine Fibroids 2023
- Estimation of the polymorphism of matrix metal proteinase genes in patients with endometrioid ovarian cysts 2021
- TRIM59 inhibits PPM1A through ubiquitination and activates TGF-β/Smad signaling to promote the invasion of ectopic endometrial stromal cells in endometriosis 2020
- Investigating the association of matrix metalloproteinase-2 gene variants with endometriosis in an Iranian population 2020
- Aberrant Overexpression of RNA-Editing Enzyme ADAR1 Promotes the Progression of Endometriosis 2020
- Significance of matrix metalloproteinase-9 expression in the ectopic endometrial tissue of women with endometriosis 2019
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) 2018
- The expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in the eutopic and ectopic endometrium in adenomyosis 2018
- Knockdown of long noncoding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis† 2018
- Matrix metalloproteinase and tissue inhibitors of metalloproteinases gene polymorphisms in disorders that influence fertility and pregnancy complications: A systematic review and meta-analysis 2018
- Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis 2016
- Effect of Genistein on Endometriosis Lesion, Matrix Metalloproteinase-2 and -9 Level of Endometriosis: In silico and In vivo Study 2016
- Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model 2016
- Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis? 2016
- Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis 2015
- Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis 2015
- Effect of warming Yang and removing blood stasis method on matrix metalloproteinases / tissue inhibitor metalloproteinases levels secreted by cultured endometrial cells from patients with endometriosis 2015
- Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review) 2014
- Endometrioos – anamneesist diagnoosini 2014
- Molecular Pathology and Therapy of Endometriosis: Revisited 2013
- Polimorfismos genéticos e endometriose: A contribuição dos genes que regulam a função vascular e o remodelamento de tecidos 2012
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- Endometriosis and Angiogenic Factors 2012
- Preliminary study on the effects of carbon dioxide and nitrogen pneumoperitoneums on endometriotic lesions 2012
- Insights into Assessing the Genetics of Endometriosis 2012
- Survivin promoter polymorphisms and autoantibodies in endometriosis 2012
- Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion 2012
- Polimorfismos genéticos e endometriose: A contribuição dos genes que regulam a função vascular e o remodelamento de tecidos 2012
- Association Between <scp><i>MMP‐2</i></scp> and <scp><i>TIMP‐2</i></scp> Gene Polymorphisms and Advanced‐Stage Endometriosis in <scp>K</scp>orean Women 2012
- Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women 2010
- Mediadores inflamatórios na dor pélvica crônica identificação de possíveis marcadores séricos da doença 2010
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