Significance of matrix metalloproteinase-9 expression in the ectopic endometrial tissue of women with endometriosis

AshrafM Kansouh, AbdElatif M. Elbalshy, SamarE Ghanem
In: Journal of Medicine in Scientific Research · 2019 · vol. 2(1) , pp. 59 · doi:10.4103/jmisr.jmisr_76_18 · W2989570705
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This study evaluated MMP-9 expression in ectopic and eutopic endometrial tissue from women with and without endometriosis, finding significantly increased MMP-9 in ectopic tissue of endometriosis patients.

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This original study evaluated matrix metalloproteinase-9 (MMP-9) expression in ectopic versus eutopic endometrial tissue from women with endometriosis compared with fertile controls. Using immunohistochemical detection in tissue sections, the authors analyzed samples from 56 participants divided into 28 infertile endometriosis patients with confirmed endometriotic implants and 28 fertile controls with normal findings. They found a significant increase in MMP-9 expression in the ectopic endometrial tissue of women with endometriosis. The paper concludes that MMP-9 could serve as a marker for endometriosis and may play a role in its progression. This paper is centrally about endometriosis — it focuses on MMP-9 expression in ectopic and eutopic endometrial tissue in women with endometriosis.

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Abstract

BackgroundDegradation of the extracellular matrix is a basic step in the formation of endometriosis. The extracellular matrix degradation operated by matrix metalloproteinases (MMPs) Because matrix metalloproteinases (MMPs) are essential in orchestrating proper physiological functioning of the endometrium. MMP-9 is affected by many factors such as prostaglandin E2, tumor necrosis factor-α, interleukin 1β, interferon-γ, and tissue inhibitors of matrix metalloproteinase.ObjectiveThe aim of the present study was to evaluate MMP-9 forms in the ectopic and eutopic endometrial tissue of women with endometriosis.Patients and methodsThe study was carried upon 56 patients. Patients were divided into two groups (study and control). The study group included 28 patients, which were infertile, and in whome diagnostic laparoscopy, open laparotomy or hysterectomy for non-malignant lesions (fibroids) showed endometriotic implants. Control group included the other 28 patients, which were normal and fertile. Specimens were prepared and MMPs-9 was immunohistochemically detected and assessed in tissue sections.ResultsThe results of the current study showed a significant increase in MMP-9 expression in the ectopic endometrial tissue of women with endometriosis.ConclusionMMP-9 could be considered a good marker for endometriosis and might play a significant role in the progression of endometriosis.
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Abstract Background Degradation of the extracellular matrix is a basic step in the formation of endometriosis. The extracellular matrix degradation operated by matrix metalloproteinases (MMPs) Because matrix metalloproteinases (MMPs) are essential in orchestrating proper physiological functioning of the endometrium. MMP-9 is affected by many factors such as prostaglandin E2, tumor necrosis factor-α, interleukin 1β, interferon-γ, and tissue inhibitors of matrix metalloproteinase. Objective The aim of the present study was to evaluate MMP-9 forms in the ectopic and eutopic endometrial tissue of women with endometriosis. Patients and methods The study was carried upon 56 patients. Patients were divided into two groups (study and control). The study group included 28 patients, which were infertile, and in whome diagnostic laparoscopy, open laparotomy or hysterectomy for non-malignant lesions (fibroids) showed endometriotic implants. Control group included the other 28 patients, which were normal and fertile. Specimens were prepared and MMPs-9 was immunohistochemically detected and assessed in tissue sections. Results The results of the current study showed a significant increase in MMP-9 expression in the ectopic endometrial tissue of women with endometriosis. Conclusion MMP-9 could be considered a good marker for endometriosis and might play a significant role in the progression of endometriosis. Article Type Original Study Recommended Citation M. Elbalshy, Abd Elatif; Kansouh, Ashraf M.; and Ghanem, Samar E. (2019) "Significance of matrix metalloproteinase-9 expression in the ectopic endometrial tissue of women with endometriosis," Journal of Medicine in Scientific Research: Vol. 2: Iss. 1, Article 9. DOI: https://doi.org/10.4103/JMISR.JMISR_76_18

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