Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women

Shan Kang, Kang S, Xi-Wa Zhao, Zhao XW, Xiwa Zhao, Na Wang, Wang N, Chen SC, Shu-Cheng Chen, Shu‐Cheng Chen, Rong‐Miao Zhou, Rong-Miao Zhou, Zhou RM, Yan Li, Li Y
Fertility and sterility · 2008 · vol. 90(5) , pp. 2023–2029 · doi:10.1016/j.fertnstert.2007.09.068 · PMID:18177649 · W2007923745
article OA: bronze CC0 ⤵ 16 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

This study examined MMP-2 and TIMP-2 gene polymorphisms and found the TIMP-2 -418C/C homozygote may protect against endometriosis in North Chinese women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-aged women with and without endometriosis. Our results indicate that the TIMP-2 -418C/C homozygote may be a protective factor against the development of endometriosis in North Chinese women.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Asian People Endometriosis Matrix Metalloproteinase 2 Polymorphism, Single Nucleotide Tissue Inhibitor of Metalloproteinase-2 Adult Asian People Case-Control Studies China China Endometriosis Endometriosis Endometriosis Female Gene Frequency Genetic Predisposition to Disease Humans Linkage Disequilibrium Matrix Metalloproteinase 2 Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (16)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:42.556217+00:00
License: CC0 · commercial use OK