Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women

Shan Kang, Kang S, Xi-Wa Zhao, Zhao XW, Xiwa Zhao, Na Wang, Wang N, Chen SC, Shu-Cheng Chen, Shu‐Cheng Chen, Rong‐Miao Zhou, Rong-miao Zhou, Zhou RM, Yan Li, Li Y
Fertility and sterility · 2008 · vol. 90(5) , pp. 2023–2029 · doi:10.1016/j.fertnstert.2007.09.068 · PMID:18177649 · W2007923745
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This study examined MMP-2 and TIMP-2 gene polymorphisms and found the TIMP-2 -418C/C homozygote may protect against endometriosis in North Chinese women.

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Abstract

We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-aged women with and without endometriosis. Our results indicate that the TIMP-2 -418C/C homozygote may be a protective factor against the development of endometriosis in North Chinese women.

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Condition tags

endometriosis

MeSH descriptors

Asian People Endometriosis Matrix Metalloproteinase 2 Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Tissue Inhibitor of Metalloproteinase-2 Adult Adult Asian People Asian People Case-Control Studies Case-Control Studies China China China Endometriosis Endometriosis Endometriosis Endometriosis Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (36)

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