Endometriosis and Angiogenic Factors

P. G.; Pedro J Grases G; M. Ruggiero; María Ruggiero; Francesca Papini; F. Papini; G. Simi; Vito Cela; V. Cela; Alvarez Zamora R; A. R.

doi:10.5772/29121

Endometriosis and Angiogenic Factors

P. G., Pedro J Grases G, M. Ruggiero, María Ruggiero, Francesca Papini, F. Papini, G. Simi, Vito Cela, V. Cela, Alvarez Zamora R, A. R.

Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/29121 · W1486805211

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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

Endometriotic implants require neovascularization for establishment and maintenance, driven by interactions between ectopic endometrium and peritoneal tissue.

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Abstract

The development of new blood vessels represents a crucial step during the establishment of endometriosis because endometriotic implants require neovascularization to guarantee oxygen and essential nutrient supply (Groothuis et al., 2005; McLaren, 2000). The interaction between the ectopic endometrium and the peritoneal tissue is a prerequisite for the induction of angiogenesis and the maintenance of endometriosis

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endometriosis

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[1] Abnormal Interleukin-1 Receptor Type II Gene Expression in the Endometrium of Women with Endometriosis1 via openalex

[2] Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis via openalex

[3] Adverse effects on sperm movement characteristics in women with minimal and mild endometriosis via openalex

[4] Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues via openalex

[5] A Modified Baboon Model for Endometriosis via openalex

[6] Analysis of two polymorphisms in the promoter region of matrix metalloproteinase 1 and 3 genes in women with endometriosis via openalex

[7] Angiogenesis and its control in the female reproductive system via openalex

[8] Association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women via openalex

[9] Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-beta1 and bax genes via openalex

[10] Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis via openalex

[11] Basal release of urokinase plasminogen activator, plasminogen activator inhibitor-1, and soluble plasminogen activator receptor from separated and cultured endometriotic and endometrial stromal and epithelial cells via openalex

[12] Behaviour of Cytokine Levels in Serum and Peritoneal Fluid of Women with Endometriosis via openalex

[13] Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis via openalex

[14] Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture via openalex

[15] Decreased Expression of the Decoy Interleukin-1 Receptor Type II in Human Endometriosis via openalex

[16] Differential Regulation of Matrix Metalloproteinase-3 Gene Expression in Endometriotic Lesions Compared with Endometrium1 via openalex

[17] Dysregulated Expression of<i>ebaf</i>, a Novel Molecular Defect in the Endometria of Patients with Infertility<sup>1</sup> via openalex

[18] Early endometriosis invades the extracellular matrix via openalex

[19] Early endometriosis invades the extracellular matrix via openalex

[20] Effect of GnRH II and GnRH I on secretion of VEGF by eutopic and ectopic endometrial stromal cells of endometriosis patients. via openalex

[21] Effect of interleukin-1 on gamete interaction and mouse embryo development. via openalex

[22] Effects of hormones on uPA, PAI‐1 and suPAR from cultured endometrial and ovarian endometriotic stromal cells via openalex

[23] Endeometriosis: The influence of peritoneal fluid from patients with minimal stage or treated endometriosis on sperm motility parameters using computer-assisted semen analysis via openalex

[24] Endocrinology and paracrinology via openalex

[25] Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis via openalex

[26] Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment via openalex

[27] Endometriosis: Endometriosis and infertility: raised iron concentration in the peritoneal fluid and its effect on the acrosome reaction via openalex

[28] Endometriosis: Secretion of interleukin-6 by human endometriotic cells and regulation by proinflammatory cytokines and sex steroids via openalex

[29] Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis<sup>1</sup> via openalex

[30] Estradiol and Interleukin-1β Exert a Synergistic Stimulatory Effect on the Expression of the Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted in Endometriotic Cells via openalex

[31] Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9 via openalex

[32] Expression of Cyclooxygenase-2 and Matrix Metalloproteinase-2 in Adenomyosis and Endometrial Polyps and its Correlation With Angiogenesis via openalex

[33] Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis via openalex

[34] Expression of transforming growth factor β1 in nerve fibers is related to dysmenorrhea and laparoscopic appearance of endometriotic implants via openalex

[35] [Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in ectopic and eutopic endometrium]. via openalex

[36] Extracellular matrix metalloproteinase inducer expression in the baboon endometrium: menstrual cycle and endometriosis via openalex

[37] Further Studies on Experimental Endometriosis via openalex

[38] Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: Significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis via openalex

[39] Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression via openalex

[40] Genetics of endometriosis via openalex

[41] Gonadotropin-releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis via openalex

[42] High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata via openalex

[43] IL‐1β TNF‐α, and IL‐2 in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis via openalex

[44] Immunohistochemical analysis of vascular endothelial growth factor cellular expression in ovarian endometriomata via openalex

[45] Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis via openalex

[46] Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis via openalex

[47] Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1 via openalex

[48] Influence of peritoneal fluid on the expression of angiogenic and proteolytic factors in cultures of endometrial cells from women with endometriosis via openalex

[49] Inhibition of transcription, expression, and secretion of the vascular epithelial growth factor in human epithelial endometriotic cells by romidepsin via openalex

[50] Interleukin‐1: A possible role in the infertility associated with endometriosis via openalex

[51] Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1 via openalex

[52] Interleukin-8 stimulates the adhesion of endometrial stromal cells to fibronectin via openalex

[53] Local activation of TGF-beta1 at endometriosis sites. via openalex

[54] Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis via openalex

[55] Matrix Metalloproteinase-3 mRNA: A Promising Peripheral Blood Marker for Diagnosis of Endometriosis via openalex

[56] Matrix metalloproteinases are elevated in the urine of patients with endometriosis via openalex

[57] Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium via openalex

[58] Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. via openalex

[59] Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9 via openalex

[60] Morphometric study of the stromal vascularization in peritoneal endometriosis via openalex

[61] Pathogenetic Significance of Increased Levels of Interleukin-8 in the Peritoneal Fluid of Patients with Endometriosis via openalex

[62] Peritoneal fluid cytokines and the relationship with endometriosis and pain via openalex

[63] Peritoneal Fluid lnterleukin‐1β and Tumor Necrosis Factor in Patients With Benign Gynecologic Disease via openalex

[64] Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-α in women with endometriosis via openalex

[65] Peritoneal interleukin-10 increases with decrease in activated CD4+ T lymphocytes in women with endometriosis via openalex

[66] Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis via openalex

[67] Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis via openalex

[68] Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial via openalex

[69] Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model via openalex

[70] Regulation of Angiogenic Growth Factors in the Female Reproductive Tract by Estrogens and Progestins via openalex

[71] Release of tumor necrosis factor-α by human peritoneal macrophages in vivo and in vitro via openalex

[72] Role of cytokines in endometriosis via openalex

[73] Role of Cytokines in Endometriosis-Associated Infertility via openalex

[74] Sperm phagocytosis by human peritoneal macrophages: A possible cause of infertility in endometriosis via openalex

[75] Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice via openalex

[76] The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro via openalex

[77] The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro via openalex

[78] The Peritoneal Fluid Levels of Interleukin‐12 in Women with Endometriosis via openalex

[79] The staging of peritoneal endometriosis by the type of active lesion in addition to the revised American Fertility Society classification via openalex

[80] The vascular endothelial growth factor +405G>C polymorphism in endometriosis via openalex

[81] Tumor Necrosis Factor- Promotes Proliferation of Endometriotic Stromal Cells by Inducing Interleukin-8 Gene and Protein Expression via openalex

[82] Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex

[83] Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue via openalex

[84] Vascular development in endometriosis via openalex

[85] Vascular endothelial growth factor and endometriotic angiogenesis via openalex

[86] Vascular endothelial growth factor and its soluble receptor in benign and malignant ovarian tumors via openalex

[87] Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex

[88] W2053212420 via openalex

[89] W2052734866 via openalex

[90] W2051978298 via openalex

[91] W2089002446 via openalex

[92] W2090025110 via openalex

[93] W2091557419 via openalex

[94] W2095498651 via openalex

[95] W2096190665 via openalex

[96] W2100258830 via openalex

[97] W2044069347 via openalex

[98] W2102156468 via openalex

[99] W2042642675 via openalex

[100] W2036430467 via openalex