Early endometriosis invades the extracellular matrix
article
OA: closed
CC0
⤵ 119 in-corpus citations
AI-generated summary
Aminoterminal propeptide of type III procollagen was elevated in peritoneal fluid of women with early endometriosis, indicating active extracellular matrix invasion.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
OBJECTIVES: To investigate whether the aminoterminal propeptides of type III procollagen are increased in patients with early endometriosis and to demonstrate that the subtle lesion of endometriosis is an active stage of the disease. DESIGN: Aminoterminal propeptide of type III procollagen was determined in serum and peritoneal fluid (PF) of 100 consecutive patients undergoing laparoscopy. SETTING: Academisch Ziekenhuis Maastricht, The Netherlands, a tertiary care center. RESULTS: Aminoterminal propeptide PF levels were significantly higher in women with early lesions of endometriosis compared with levels in two groups of controls, i.e., fertile, cycling, women without the disease (P = 0.019) and women on oral contraceptives without the disease (P = 0.036). No difference was found in aminoterminal propeptide PF levels when comparing patients with early lesions of endometriosis and patients with unexplained infertility, the third control group. Aminoterminal propeptide PF levels of patients with endometriosis without early lesions were not different from PF levels in controls. CONCLUSION: The early lesion is an active stage of endometriosis, invading the extracellular matrix. In women with unexplained infertility active, microscopic endometriosis may be present.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (21)
- Altered maturation and function of peritoneal macrophages: Possible role in pathogenesis of endometriosis via openalex
- Functional aspects of peritoneal macrophages in endometriosis of women via openalex
- Nonpigmented endometriosis: Clinical, laparoscopic, and pathologic definition via openalex
- Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
- The basement membrane in endometriosis via openalex
- The second-look laparoscopy for evaluation of the result of medical treatment of endometriosis should not be performed during ovarian suppression via openalex
- W2131515651 via openalex
- W2158091948 via openalex
- W2165845645 via openalex
- W2406042991 via openalex
- W2409510670 via openalex
- W2412302453 via openalex
- W2414039702 via openalex
- W2477008945 via openalex
- W73242332 via openalex
- W3207369619 via openalex
- W1967741494 via openalex
- W1997427129 via openalex
- W2006918064 via openalex
- W2027898835 via openalex
- W2068511555 via openalex
Cited by (50)
- Endometriosis diagnosis and medical treatment: Present and future 2021
- Potential use of ellagic acid for endometriosis treatment: its effect on a human endometrial cell cycle, adhesion and migration 2020
- Iron-Storage Protein Ferritin Is Upregulated in Endometriosis and Iron Overload Contributes to a Migratory Phenotype 2020
- Curcumin and Endometriosis 2020
- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights 2019
- Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms 2019
- Polychlorinated biphenyl 104 promotes migration of endometrial stromal cells in endometriosis 2018
- Identifying biomarkers for non-invasive diagnosis of endometriosis 2016
- Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway 2015
- Molecular aspects of endometriosis 2015
- Melatonin and genital endometriosis - new possibilities of therapy 2015
- Hypoxia Promotes Invasion of Endometrial Stromal Cells via Hypoxia-Inducible Factor 1α Upregulation-Mediated β-Catenin Activation in Endometriosis 2015
- Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis 2014
- Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review) 2014
- BRCA1 alterations are associated with endometriosis, but BRCA2 alterations show no detectable endometriosis risk: a study in Indian population 2014
- Molecular aspects of development and regulation of endometriosis 2014
- Study of ultrastructure and apoptosis in the endometrium of women with or without endometriosis. 2013
- Mitochondrial displacement loop alterations are associated with endometriosis 2013
- Mitochondrial NADH:ubiquinone oxidoreductase alterations are associated with endometriosis 2013
- Videothoracoscopic Repair of Diaphragm and Pleurectomy/Abrasion in Patients With Catamenial Pneumothorax 2013
- The Local Immune Mechanisms Involved in the Formation of Endometriotic Lesions 2012
- RNAi-mediated blocking of ezrin reduces migration of ectopic endometrial cells in endometriosis 2012
- Endometriosis and Angiogenic Factors 2012
- Mitochondrial Genome Variations in Advanced Stage Endometriosis: A Study in South Indian Population 2012
- Endometriosis: Disease Classification and Behavior 2011
- Theories on the Pathogenesis of Endometriosis 2011
- Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities 2011
- Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis 2011
- Association of E-cadherin single nucleotide polymorphisms with the increased risk of endometriosis in Indian women 2011
- Pathophysiological factors and genetic association in endometriosis 2011
- Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells 2010
- Pathogenesis of Endometriosis 2010
- Apoptosis and endometriosis 2010
- Cyclic sciatica from extrapelvic endometriosis affecting the sciatic nerve 2010
- Baboon Model for Endometriosis 2009
- Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model 2009
- Apoptosis in Endometriosis 2009
- Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model 2009
- Regulation and activation of ezrin protein in endometriosis 2008
- Fibromuscular differentiation in deeply infiltrating endometriosis is a reaction of resident fibroblasts to the presence of ectopic endometrium 2008
- Combination of estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine secretion and invasion of endometrial stromal cells 2008
- Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis 2008
- Matrix metalloproteinases 2 and 9, E-cadherin, and β-catenin expression in endometriosis, low-grade endometrial carcinoma and non-neoplastic eutopic endometrium 2008
- Role of melatonin in regulating matrix metalloproteinase‐9 via tissue inhibitors of metalloproteinase‐1 during protection against endometriosis 2008
- Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population 2007
- Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry 2007
- Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells 2007
- Trichostatin A, a Histone Deacetylase Inhibitor, Attenuates Invasiveness and Reactivates E-Cadherin Expression in Immortalized Endometriotic Cells 2007
- Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression 2007
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? 2006
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:11:44.647872+00:00
- unpaywall
- last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0
· commercial use OK