The second-look laparoscopy for evaluation of the result of medical treatment of endometriosis should not be performed during ovarian suppression

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AI-generated summary by claude@2026-06, 2026-06-06

This study investigated the optimal timing for second-look laparoscopy after medical treatment for endometriosis, recommending against performing it during periods of ovarian suppression.

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Abstract

Some authors have evaluated the efficacy of medical treatment for endometriosis by SLL at termination of therapy. The appearance of endometriotic lesions depends on ovarian activity. We studied the appearance of endometriotic lesions at SLL during the last week of treatment with danazol and compared it with the appearance of SLL in the second cycle after the end of treatment. A difference was noted and was attributed to the effect of stimulation of the endometriotic foci by ovarian activity. Danazol does not eradicate endometriosis. When suppression is discontinued, the disease will return with time. We conclude that performing an SLL during ovarian suppression, for evaluation of the effect of medical therapy of endometriosis, is a misleading procedure.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Ovary Pelvic Neoplasms Pregnadienes Clinical Trials as Topic Danazol Endometriosis Endometriosis Female Humans Laparoscopy Ovary Pelvic Neoplasms Pelvic Neoplasms Pregnadienes Random Allocation

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Cited by (50)

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europepmc
last seen: 2026-08-04T06:16:37.499272+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:09:30.565292+00:00
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