Endometriosis

Serdar E. Bulun

doi:10.1016/b978-0-323-47912-7.00025-1

Endometriosis

Serdar E. Bulun

In: Yen and Jaffe's Reproductive Endocrinology · 2019 · pp. 609–642.e7 · doi:10.1016/b978-0-323-47912-7.00025-1 · W4239427864

book-chapter OA: closed CC0 ⤵ 7 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper provides an overview of endometriosis, covering its definition, pathogenesis, diagnosis, and management strategies.

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Condition tags

endometriosis

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References (100)

Cited by (7)

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[1] Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis via openalex

[2] Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells via openalex

[3] Aberrant integrin expression in the endometrium of women with endometriosis via openalex

[4] Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis via openalex

[5] Accuracy of transvaginal ultrasound for diagnosis of deep endometriosis in uterosacral ligaments, rectovaginal septum, vagina and bladder: systematic review and meta‐analysis via openalex

[6] Activation of mutated K‐ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis via openalex

[7] Add-back therapy and gonadotropin-releasing hormone agonists in the treatment of patients with endometriosis: can a consensus be reached? via openalex

[8] Administration of Nasal Nafarelin as Compared with Oral Danazol for Endometriosis via openalex

[9] A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese via openalex

[10] A gonadotropin-releasing hormone agonist versus a continuous oral contraceptive pill in the treatment of bladder endometriosis via openalex

[11] A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis via openalex

[12] Altered Retinoid Uptake and Action Contributes to Cell Survival in Endometriosis via openalex

[13] Anastrazole and oral contraceptives: a novel treatment for endometriosis via openalex

[14] A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis via openalex

[15] A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis via openalex

[16] Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis via openalex

[17] Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target via openalex

[18] Aromatase expression in endometriosis via openalex

[19] Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis via openalex

[20] Aromatase inhibitors: the next generation of therapeutics for endometriosis? via openalex

[21] Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons via openalex

[22] Association between chronic pelvic pain symptoms and the presence of endometriosis via openalex

[23] A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes via openalex

[24] Beyond infertility: obstetrical and postpartum complications associated with endometriosis and adenomyosis via openalex

[25] ‘Blood On The Tracks’ from corpora lutea to endometriomas* via openalex

[26] Cancer-Associated Mutations in Endometriosis without Cancer via openalex

[27] Cancer Implications for Patients with Endometriosis via openalex

[28] Catamenial pneumothorax revisited: Clinical approach and systematic review of the literature via openalex

[29] Celecoxib in the treatment of primary dysmenorrhea: Results from two randomized, double-blind, active- and placebo-controlled, crossover studies via openalex

[30] Central and Peripheral Pain Generators in Women with Chronic Pelvic Pain: Patient Centered Assessment and Treatment via openalex

[31] Central changes associated with chronic pelvic pain and endometriosis via openalex

[32] Chemokine bioactivity of RANTES in endometriotic and normal endometrial stromal cells and peritoneal fluid via openalex

[33] Chocolate cysts from ovarian follicles via openalex

[34] Coding regions of INHBA, SFRP4 and HOXA10 are not implicated in familial endometriosis linked to chromosome 7p13–15 via openalex

[35] Committee Opinion No. 663 via openalex

[36] Common Variation in the CYP17A1 and IFIT1 Genes on Chromosome 10 Does Not Contribute to the Risk of Endometriosis via openalex

[37] Conservative surgical management of endometriosis in women with pelvic pain via openalex

[38] Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis via openalex

[39] COX-2 Inhibitors and Their Role in Gynecology via openalex

[40] Cutting SRC-1 down to size in endometriosis via openalex

[41] Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium via openalex

[42] Danazol inhibition of steroidogenesis in the human corpus luteum. via openalex

[43] Deep endometriosis conundrum: evidence in favor of a peritoneal origin via openalex

[44] Deep endometriosis: definition, diagnosis, and treatment via openalex

[45] Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management via openalex

[46] Diagnostic accuracy of transvaginal ultrasound for non‐invasive diagnosis of bowel endometriosis: systematic review and meta‐analysis via openalex

[47] Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex

[48] Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis via openalex

[49] Does Disruption of Immune and Endocrine Systems by Environmental Toxins Contribute to Development of Endometriosis? via openalex

[50] Effect of early endometriosis on ovarian reserve and reproductive outcome via openalex

[51] Effect of endometriosis on in vitro fertilization via openalex

[52] Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex

[53] Effects of the levonorgestrel-releasing intrauterine system on cell proliferation, Fas expression and steroid receptors in endometriosis lesions and normal endometrium via openalex

[54] Effects of the Progesterone Receptor Modulator VA2914 in a Continuous Low Dose on the Hypothalamic-Pituitary-Ovarian Axis and Endometrium in Normal Women: A Prospective, Randomized, Placebo-Controlled Trial via openalex

[55] Elagolix, an Oral GnRH Antagonist, Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis: Effects on Bone Mineral Density via openalex

[56] Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis via openalex

[57] Endometrial expression of estrogen receptor β and its splice variants in patients with and without endometriosis via openalex

[58] Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis via openalex

[59] Endometriosis via openalex

[60] Endometriosis via openalex

[61] Endometriosis via openalex

[62] Endometriosis. via openalex

[63] Endometriosis: Advanced Management and Surgical Techniques via openalex

[64] Endometriosis: a dysfunction and disease of the archimetra via openalex

[65] Endometriosis and Infertility via openalex

[66] Endometriosis-associated pelvic pain: evidence for an association between the stage of disease and a history of chronic pelvic pain via openalex

[67] Endometriosis: Diagnosis and Management via openalex

[68] Endometriosis: epidemiology and aetiological factors via openalex

[69] Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action via openalex

[70] Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex

[71] Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion via openalex

[72] Endometriosis: pathogenesis and treatment via openalex

[73] Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex

[74] Endometriotic ovarian cysts do not negatively affect the rate of spontaneous ovulation via openalex

[75] Endoscopic versus laparotomy management of endometriomas via openalex

[76] Enhanced Expression of Resident Leukocyte Interferon γ mRNA in Endometriosis via openalex

[77] Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas via openalex

[78] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[79] Epidemiology of endometriosis in women attending family planning clinics. via openalex

[80] ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via Ras-like and Estrogen-Regulated Growth Inhibitor in Endometriosis via openalex

[81] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[82] Estradiol Amplifies Interleukin-1-Induced Monocyte Chemotactic Protein-1 Expression by Ectopic Endometrial Cells of Women with Endometriosis via openalex

[83] Estradiol and Interleukin-1β Exert a Synergistic Stimulatory Effect on the Expression of the Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted in Endometriotic Cells via openalex

[84] Estrogen Receptor (ER) β Regulates ERα Expression in Stromal Cells Derived from Ovarian Endometriosis via openalex

[85] Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis via openalex

[86] Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1 via openalex

[87] Expression of interleukin-8 receptors in endometriosis via openalex

[88] Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex

[89] Extrapelvic Endometriosis via openalex

[90] Familial endometriosis via openalex

[91] Fatal acute hepatic failure induced by danazol in a patient with endometriosis and aplastic anemia via openalex

[92] Functional MicroRNA Involved in Endometriosis via openalex

[93] Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis via openalex

[94] Genetic influences on endometriosis in an Australian twin sample via openalex

[95] Genetic or Enzymatic Disruption of Aromatase Inhibits the Growth of Ectopic Uterine Tissue via openalex

[96] Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets via openalex

[97] Genome-wide association meta-analysis identifies new endometriosis risk loci via openalex

[98] Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis via openalex

[99] Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis via openalex

[100] Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 via openalex