Extrapelvic Endometriosis

review OA: closed CC0 ⤵ 46 in-corpus citations
AI-generated summary by gemini-2.5-flash-lite, 2026-06-06

This review covers the pathophysiology, diagnosis, and treatment of rare extrapelvic endometriosis occurring in the umbilicus, abdominal wall, thorax, and vulva.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text

This review article examines extrapelvic endometriosis, focusing on the umbilicus, abdominal wall, thorax, and vulva, and discusses its proposed pathophysiology, clinical presentation, diagnostic approaches, and treatment recommendations. It notes that while intrapelvic endometriosis is widely attributed to retrograde menstruation, the mechanisms underlying extrapelvic disease remain elusive. Key issues highlighted include the rarity and complexity of extrapelvic manifestations and the resulting difficulty in establishing uniform diagnostic and management strategies, as well as reliance on published case reports and literature synthesis typical of reviews. This paper is centrally about endometriosis — specifically extrapelvic endometriosis across multiple non-pelvic anatomical sites.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Extrapelvic endometriosis is a rare and complex phenomenon. The pathologic mechanism of intrapelvic endometriosis is generally accepted as being largely due to retrograde menstruation through the fallopian tubes; however, the mechanism by which extrapelvic endometriosis forms has proven to be much more elusive. This article reviews the pathophysiology, clinical signs and symptoms, diagnostic techniques, and treatment recommendations for extrapelvic endometriosis of the umbilicus, abdominal wall, thorax, and vulva.
Full text 4,893 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Extrapelvic endometriosis is a rare and complex phenomenon. The pathologic mechanism of intrapelvic endometriosis is generally accepted as being largely due to retrograde menstruation through the fallopian tubes; however, the mechanism by which extrapelvic endometriosis forms has proven to be much more elusive. This article reviews the pathophysiology, clinical signs and symptoms, diagnostic techniques, and treatment recommendations for extrapelvic endometriosis of the umbilicus, abdominal wall, thorax, and vulva. -

References

- 1 Hussain M, Noorani K. Primary umbilical endometriosis--a rare variant of cutaneous endometriosis. J Coll Physicians Surg Pak 2003; 13 (3) 164-165 - 2 Sheikh HH. Extrapelvic endometriosis--an overview and case histories. Int J Fertil Womens Med 1998; 43 (1) 12-17 - 3 Steck WD, Helwig EB. Cutaneous endometriosis. Clin Obstet Gynecol 1966; 9 (2) 373-383 - 4 Goldberg JM, Bedaiwy MA. Recurrent umbilical endometriosis after laparoscopic treatment of minimal pelvic endometriosis: a case report. J Reprod Med 2007; 52 (6) 551-552 - 5 Sampson JA. Perforating hemorrhagic (chocolate) cysts of the ovary. Their importance and especially their relation to pelvic adenomas of endometrial type. Arch Surg 1921; 3: 245-323 - 6 Scott RB, Nowak RJ, Tiridale RM. Umbilical endometriosis and the collen sign. Study of lymphatic transport from pelvis to umbilicus in monkeys. Obstet Gynecol 1958; 11: 556-563 - 7 Novak E. The significance of uterine mucosa in the fallopian tube with a discussion of the origin of aberrant endometrium. Am J Obstet Gynecol 1926; 12: 484-525 - 8 Von Recklinghausen F. Adenomyomas and cystadenomas of the wall of the uterus and tube: their origin as remnants of the Wolffian body. Wein Klin Wochenschr 1896; 8: 530 - 9 Blumenthal NJ. Umbilical endometriosis. SA Med J 1981; 198-199 - 10 Sampson JA. Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927; 14: 422-469 - 11 Hartigan CM, Holloway BJ. Case report: MR imaging features of endometriosis at the umbilicus. Br J Radiol 2005; 78 (932) 755-757 - 12 Machairiotis N, Stylianaki A, Dryllis G , et al. Extrapelvic endometriosis: a rare entity or an under diagnosed condition?. Diagn Pathol 2013; 8: 194 - 13 Wolf C, Obrist P, Ensinger C. Sonographic features of abdominal wall endometriosis. AJR Am J Roentgenol 1997; 169 (3) 916-917 - 14 Francica G, Giardiello C, Angelone G, Cristiano S, Finelli R, Tramontano G. Abdominal wall endometriomas near cesarean delivery scars: sonographic and color Doppler findings in a series of 12 patients. J Ultrasound Med 2003; 22 (10) 1041-1047 - 15 Coley BD, Casola G. Incisional endometrioma involving the rectus abdominis muscle and subcutaneous tissues: CT appearance. AJR Am J Roentgenol 1993; 160 (3) 549-550 - 16 Charles SX, Samyuktha K. Endometriosis of umbilicus. Aust N Z J Obstet Gynaecol 1979; 19 (4) 239-240 - 17 Purvis RS, Tyring SK. Cutaneous and subcutaneous endometriosis. Surgical and hormonal therapy. J Dermatol Surg Oncol 1994; 20 (10) 693-695 - 18 Suginami H. A reappraisal of the coelomic metaplasia theory by reviewing endometriosis occurring in unusual sites and instances. Am J Obstet Gynecol 1991; 165 (1) 214-218 - 19 Kirschner PA. Porous diaphragm syndromes. Chest Surg Clin N Am 1998; 8 (2) 449-472 - 20 Nair SS, Nayar J. Thoracic endometriosis syndrome: a veritable Pandora's box. J Clin Diagn Res 2016; 10 (4) QR04-QR08 - 21 Korom S, Canyurt H, Missbach A , et al. Catamenial pneumothorax revisited: clinical approach and systematic review of the literature. J Thorac Cardiovasc Surg 2004; 128 (4) 502-508 - 22 Jablonski C, Alifano M, Regnard JF, Gompel A. Pneumoperitoneum associated with catamenial pneumothorax in women with thoracic endometriosis. Fertil Steril 2009; 91 (3) 930.e19-930.e22 - 23 Bagan P, Le Pimpec Barthes F, Assouad J, Souilamas R, Riquet M. Catamenial pneumothorax: retrospective study of surgical treatment. Ann Thorac Surg 2003; 75 (2) 378-381 , 381 - 24 Nominato NS, Prates LF, Lauar I, Morais J, Maia L, Geber S. Scar endometriosis: a retrospective study of 72 patients. Rev Bras Ginecol Obstet 2007; 29 (8) 423-427 - 25 Papavramidis TS, Sapalidis K, Michalopoulos N , et al. Spontaneous abdominal wall endometriosis: a case report. Acta Chir Belg 2009; 109 (6) 778-781 - 26 Kanellos I, Kelpis T, Zaraboukas T, Betsis D. Perineal endometriosis in episiotomy scar with anal sphincter involvement. Tech Coloproctol 2001; 5 (2) 107-108

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Abdominal Wall Abdominal Wall Endometriosis Endometriosis Endometriosis Endometriosis Thoracic Diseases Thoracic Diseases Thoracic Diseases Thoracic Diseases Umbilicus Umbilicus Vulvar Diseases Vulvar Diseases Vulvar Diseases Vulvar Diseases Female Humans Prognosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (46)

Source provenance

europepmc
last seen: 2026-09-16T06:11:32.772430+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:43.714878+00:00
unpaywall
last seen: 2026-09-16T06:28:21.314993+00:00
License: CC0 · commercial use OK