Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium

Matsuzaki S, Sachiko Matsuzaki, Michel Canis, Pouly JL, Jean-Luc Pouly, Jean‐Luc Pouly, Arnaud Wattiez, Kunihiro Okamura, Okamura K, Mage G, G. Mage, Gerard Mage
Fertility and sterility · 2004 · vol. 82(5) , pp. 1309–1315 · doi:10.1016/j.fertnstert.2004.03.059 · PMID:15533352 · W2078909544
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This study investigated the expression of cyclooxygenase-2 (COX-2) in deep endometriosis lesions and compared it to matched eutopic endometrial tissue from the same patients.

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Abstract

ObjectiveTo identify any relationship between cyclooxygenase-2 expression and the intensity of severe, endometriosis-related dysmenorrhea.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with deep endometriosis.Intervention(s)During surgery, paired samples of tissue representing deep endometriosis and eutopic endometrium were obtained from 46 patients. Control endometrial tissue samples were obtained from 34 fertile women who underwent laparoscopic tubal ligation or reversal of tubal sterilization. Pain assessment for dysmenorrhea was done with a 10-point linear analogue scale.Main outcome measure(s)The percentage of surface immunostained for Cox-2 was determined by an immunohistochemical technique. Relationships between pain score for dysmenorrhea and Cox-2 expression were analyzed.Result(s)Cox-2 expression was significantly higher in eutopic endometrial stromal cells from patients with deep endometriosis than in stroma from controls during the early, mid, and late secretory phases. In endometriosis patients, Cox-2 expression in eutopic endometrial stromal cells was significantly higher in women with more severe dysmenorrhea (pain score > or =7 vs. <7) during early and mid secretory phases.Conclusion(s)Elevated Cox-2 expression in stromal cells in eutopic endometrium from patients with deep endometriosis may play a role in severe, endometriosis-related dysmenorrhea.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Endometriosis Endometrium Isoenzymes Prostaglandin-Endoperoxide Synthases Adult Case-Control Studies Cyclooxygenase 2 Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunohistochemistry Immunohistochemistry Isoenzymes

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