ACUPUNCTURE IMPROVES THE EFFECTS OF CHINESE HERBAL MEDICINE IN TREATING ENDOMETRIOSIS MODEL RATS

Jinghua Shi, Zhichao Ge, Yue Jin, Y. D. Li, Jue Zhou
In: The Journal of Animal and Plant Sciences · 2013 · vol. 23(1) , pp. 298–303 · W2160007689
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Acupuncture combined with Chinese herbal medicine significantly reduced serum CA-125, peritoneal fluid IL-18, and ectopic endometrial COX-2 mRNA levels in endometriosis model rats compared to herbal medicine or Danazol alone.

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Abstract

The present study was aimed t o investigatewhether acupuncture could significantly enhance the efficacy of Chinese herbal medicine ( CHM) in treating endometriosis model rats. A total of 40female Sprague-Dawley (SD) ratswith body weight of200±20 gwere included. Operational transplantation was used with animal models. The rats were randomly divided into 5 groups: sham -operation control group (Group A), model group (Group B), CHM combined with acupuncture group (Group C ), CHM group (Group D), Danazol group (Group E) with 8 rats in each group. During the treatment, two rats in Group B and one rat in Group E passed away. When the treatment ended, all the left rats were sacrificed. The samples of peritoneal fluids, serum and the ectopic endometriumwere taken. The serum levels of cancer antigen 125 (CA-125) and interleukin 18(IL -18) in the peritoneal fluids were detected using enzyme -linked immune-sorbent assay. Thecyclooxygenase-2 (COX -2)mRNA expression levels in the ectopic endometrium were measured by Real-time PCR.The results showed that i n the rats from Groups A, C, D and E, t he serum CA-125 levels, COX -2 mRNA expression in the ectopic endometrium and the IL-18 levels in the peritoneal fluids were significantly lower than those of Group B (P 0.05).The levels of I L-18 in the peritoneal fluids of the rats in Group C were markedly lower than those of Group D and E ( P<0.05).It is then concluded that a cupuncture treatmentcan improvethe effects of CHM in treating endometriosis model rats.

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endometriosis

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