Clinical evaluation of CA-125 concentrations as a prognostic factor for pregnancy in infertile women with surgically treated endometriosis

Pittaway DE, Donald E. Pittaway, D E Pittaway, Rondinone D, Dorine Rondinone, D Rondinone, Kathleen A. Miller, K A Miller, Miller KA, Barnes K, K Barnes, K. D. Barnes
Fertility and sterility · 1995 · vol. 64(2) , pp. 321–324 · doi:10.1016/s0015-0282(16)57730-9 · PMID:7615110 · W2395214419
article OA: closed CC0 ⤵ 38 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study evaluated CA-125 concentrations as a prognostic factor for pregnancy in infertile women who underwent surgical treatment for endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo extend and confirm earlier observations that serial CA-125 determinations appear to have prognostic value in some infertile women with surgically treated endometriosis using a new automated enzyme immunoassay.DesignA prospective consecutive case series.SettingA university-based tertiary practice.PatientsOf 342 women having a laparoscopy for infertility, 123 (36%) had endometriosis. Fifty-six of 123 (45%) infertile women with endometriosis had preoperative CA-125 values > or = 16 U/mL and were followed for 12 months with serial CA-125 determinations.Main outcome measureProportion of women achieving a pregnancy within 12 months from surgery.ResultsMean preoperative CA-125 concentrations were not statistically different for women conceiving, but mean postoperative CA-125 values were significantly lower for women achieving a pregnancy. Univariate analyses indicated that preoperative CA-125 values between 16-25 U/mL and postoperative CA-125 values < 16 U/mL were associated with significantly higher pregnancy rates. Multivariate analyses of 10 covariables indicated only postoperative CA-125 concentrations to be associated with pregnancy even after controlling for all covariables.ConclusionUsing a newly developed assay for CA-125, the study confirms and extends earlier observation that CA-125 concentrations have prognostic value for pregnancy in infertile women with surgically treated endometriosis. The findings provide additional support for the clinical use of CA-125 concentrations in selected women with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

CA-125 Antigen Endometriosis Infertility, Female Adult CA-125 Antigen Endometriosis Endometriosis Female Humans Infertility, Female Pregnancy Prognosis Prospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (9)

Cited by (39)

Source provenance

europepmc
last seen: 2026-09-15T06:16:59.523076+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:13.665691+00:00
unpaywall
last seen: 2026-09-15T06:33:26.365676+00:00
License: CC0 · commercial use OK