Problems with the Diagnosis of Endometriosis
review
OA: gold
CC0
⤵ 50 in-corpus citations
AI-generated summary
This review discusses the challenges and limitations of current diagnostic methods for endometriosis, highlighting the absence of a reliable non-surgical diagnostic approach.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Endometriosis is classically defined as the presence of endometrial glands and stroma in outside the uterine cavity. As the definition suggests that confirming the ectopic endometrial stroma and glands in ectopic location histopathologically should be necessary for the diagnosis of endometriosis. Therefore, this situation leads to the need for surgery like laparoscopy for diagnosis. However, this surgical diagnostic approach will not be reliable for all patients with suspected endometriosis. It seems to be an important problem that there is still no reliable clinically diagnostic method or pathognomonic clinical finding, which may allow accurate diagnosis of endometriosis without the need for surgery or histopathologic evaluation. While these clinical features are not pathognomonic for the endometriosis, they should be used as markers for creating high-risk population for endometriosis. Clinical features and the available diagnostic methods, their advantages and limitations for the endometriosis will be discussed in this article. The different options for clinical assessment, laboratory tests and imaging techniques will be summarized and the advantages and disadvantages of these methods will be evaluated. We will also discuss the gold standard definitive diagnostic options with their problematic aspects.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (31)
- CA 125 levels measured in different phases of the menstrual cycle in screening for endometriosis. via openalex
- Clinical evaluation of CA-125 concentrations as a prognostic factor for pregnancy in infertile women with surgically treated endometriosis via openalex
- Diagnosis of deep endometriosis by clinical examination during menstruation and plasma CA-125 concentration via openalex
- Diagnosis of deep endometriosis by clinical examination during menstruation and plasma CA-125 concentration. via openalex
- Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis via openalex
- Endometriosis via openalex
- Endometriosis: Appearance and detection with conventional and contrast‐enhanced fat‐suppressed spin‐echo techniques via openalex
- Endometriosis: Correlation between histologic and visual findings at laparoscopy via openalex
- Endometriosis: The bubble test: a new tool to improve the diagnosis of endometriosis* via openalex
- Nonpigmented endometriosis: Clinical, laparoscopic, and pathologic definition via openalex
- Pelvic endometriosis: detection and diagnosis with chemical shift MR imaging. via openalex
- Peritoneal blood painting: An aid in the diagnosis of endometriosis via openalex
- Reliability of the visual diagnosis of ovarian endometriosis via openalex
- Role of imaging in the management of endometriosis. via openalex
- Routine Clinical Examination Is Not Sufficient for Diagnosing and Locating Deeply Infiltrating Endometriosis via openalex
- Serum CA-125 concentrations during midfollicular phase, a clinically useful and reproducible marker in diagnosis of advanced endometriosis via openalex
- Serum CA-125 in preoperative patients at high risk for endometriosis via openalex
- Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts via openalex
- Stenosis of the external cervical os: an association with endometriosis in women with chronic pelvic pain via openalex
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis via openalex
- Tumor markers in endometriosis via openalex
- Validation study of nonsurgical diagnosis of endometriosis via openalex
- Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study via openalex
- W2085729837 via openalex
- W73385028 via openalex
- W190587926 via openalex
- W1997312656 via openalex
- W2001497923 via openalex
- W18374401 via openalex
- W2096141938 via openalex
- W2400692327 via openalex
Cited by (50)
- Bridging the Diagnostic Gap: Reviewing Current Endometriosis Screening Tools and Models 2026
- Navigating endometriosis diagnostic delay in 2040: Future directions in noninvasive diagnosis 2026
- The Endometriosis-Related Healthcare Experiences of Regional Australian Women: A Qualitative Systematic Review 2026
- Transcriptome profiling to identify blood biomarkers for peritoneal endometriosis 2025
- Specializing Care, (Re)Producing Inequalities: Who Is Excluded from Endometriosis? 2025
- Phytoestrogens: A Promising Therapeutic Approach for Endometriosis Management, Insights from Preclinical and Clinical Studies 2025
- “We’re Just Walking Experiments”: Exploring Uncertainty Management of Endometriosis 2025
- Endometriosis as an autoimmune disease 2024
- Starting the Conversation about Barriers for Endometriosis Care in Regional Areas: An Autoethnographic Perspective 2024
- Rare but Still There: A Scoping Review on Endometriosis-Associated Ovarian Cancer 2024
- Ultrasound image-based deep learning to differentiate tubal-ovarian abscess from ovarian endometriosis cyst 2023
- Mobile applications for endometriosis management functionalities: Analysis and potential 2023
- Unmet needs of Australians in endometriosis research: a qualitative study of research priorities, drivers and barriers to participation 2023
- Unmet Needs of Australians in Endometriosis Research: A Qualitative Study of Research Priorities, Drivers, and Barriers to Participation in People with Endometriosis 2023
- GC-MS analysis of the composition of serum IgG glycans as a potential diagnostic marker of advanced endometriosis - Preliminary report 2023
- Endometriose des Uro-Genitaltraktes 2023
- ENDOMETRIOSE 2023
- ENDOMETRIOSE 2023
- Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis 2023
- Endometrioma Unveiled: A Comprehensive Review of the Pathogenesis, Diagnosis, and Current Management Strategies of Ovarian Endometriosis 2023
- Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis 2023
- Endometriose des Uro-Genitaltraktes 2022
- Expressão diferencial de genes e microRNAs relacionados com as vias de adesão e apoptose nos diferentes fenótipos de pacientes com endometriose 2022
- Analysis of cell immune regulation features in recurrent ovarian endometriosis 2022
- Gastrointestinal symptoms as a predictor of deep endometriosis of the pelvic posterior compartment on magnetic resonance imaging 2022
- Obturator nerve endometriosis: A systematic review of the literature 2022
- MicroRNAs Dysregulation as Potential Biomarkers for Early Diagnosis of Endometriosis 2022
- Examining Diagnostic Options and Classification Systems Available for Endometriosis 2021
- The immune system and endometriosis 2021
- Endometriose Aspectos clínicos do diagnóstico ao tratamento 2021
- Application of serum markers in diagnosis and staging of ovarian endometriosis 2021
- Levels of endoplasmic reticulum stress-related mRNA in peritoneal fluid of patients with endometriosis or gynaecological cancer 2021
- Levels of endoplasmic reticulum stress-related mRNA in peritoneal fluid of patients with endometriosis or gynaecological cancer 2021
- Contemporary approach to diagnostics in women with suspected pelvic endometriosis 2021
- Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis 2021
- Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review 2020
- Deoxyribonucleic acid and chromatin imaging of endometriosis and endometrial carcinoma using atomic force microscopy 2019
- Positron emission tomography imaging of vascular endothelial growth factor with <sup>64</sup> Cu-labeled bevacizumab for non-invasive diagnosis of endometriosis 2019
- How Can Mitochondrial Dna Deletions Act As A Biomarker for the Detection of Endometriosis Within the Clinic? 2019
- Endometriosis-Associated Ovarian Cancer 2018
- Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development 2018
- Differences in C-type lectin receptors and their adaptor molecules in the peritoneal fluid of patients with endometriosis and gynecologic cancers 2018
- Gene Polymorphisms in FAS (Rs3740286 and Rs4064) Are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815) 2018
- The Endometriosis Fertility Index Is Useful for Predicting the Ability to Conceive without Assisted Reproductive Technology Treatment after Laparoscopic Surgery, Regardless of Endometriosis 2017
- Differential expression of EWI‐2 in endometriosis, its functional role and underlying molecular mechanisms 2017
- Obturator Internus Muscle Endometriosis with Nerve Involvement: a Rare Clinical Presentation 2017
- Differential expression of EWI‐2 in endometriosis, its functional role and underlying molecular mechanisms 2017
- Endometriose — ein Überblick 2017
- Ovarian suspension for adhesion prevention during laparoscopic excision of severe pelvic endometriosis and endometrioma excision: a systematic review 2016
- Medicinal plants and natural compounds in the treatment of experimental endometriosis: A systematic review protocol 2016
Source provenance
- europepmc
- last seen: 2026-09-21T06:08:07.822426+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:17:39.907309+00:00
License: CC0
· commercial use OK