The immune system and endometriosis

Leila Appazova, Lyudmila Akhmaltdinova
In: Journal "Medicine" · 2021 · vol. 5-6(215-216) , pp. 71–77 · doi:10.31082/1728-452x-2020-215-216-5-6-71-77 · W3177361550
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This review analyzes literature to explore the role of the immune system, particularly cytokines and autoantibodies, in the pathogenesis of endometriosis, highlighting the need for better understanding to identify therapeutic targets.

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This article is a literature review analyzing evidence on how the immune system contributes to the pathogenesis of endometriosis, focusing on immunologic features, cytokines, and autoantibodies. The authors searched PubMed/MEDLINE, PMC, and Web of Science for key studies on genital endometriosis and immune mechanisms published within the previous 10 years, including meta-analyses, original, retrospective, and cohort studies. The review concludes that cytokine roles in endometriosis are established but not sufficiently studied, making it difficult to clarify how they influence disease development, and that further research is needed to improve diagnostic and treatment approaches; the main limitation is that the conclusions rely on heterogeneous published literature rather than new primary data. This paper is centrally about endometriosis — it specifically analyzes the immune system, cytokines, and autoantibodies in endometriosis pathogenesis.

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Abstract

The article analyzes the literature data on the immune system and endometriosis. The features of the immune system, as well as the mechanisms of endometriosis development in the case of immune system dysfunction, are considered. Aim. To study the role of the immune system in the pathogenesis of endometriosis. Material and methods. To analyze the literature, we searched for information about this problem up to 10 years deep in PubMed/MEDLINE, PMC, and Web of Sсiеnce. The following terms were used individually or in combination: "genital endometriosis", "immune system", "cytokines", "autoantibodies". The search criteria were key studies related to genital endometriosis and the immune system: meta-analyses, original studies, retrospective and cohort studies. Results and discussion. There is a need to improve understanding of the potential origin of the General immunopathophysiology of endometriosis in order to identify therapeutic target areas that may allow relief or, ultimately, prevention of this disease. Immunological markers in this aspect have certain prospects. Conclusion. Although the role of cytokines in the development of endometriosis has been determined, it is not well understood. In this regard, it is difficult to clearly determine how they affect the pathogenesis of endometriosis. Keywords: endometriosis, immune system, cytokines, autoantibodie.
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ИММУННАЯ СИСТЕМА И ЭНДОМЕТРИОЗ DOI: https://doi.org/10.31082/1728-452X-2020-215-216-5-6-71-77Ключевые слова: эндометриоз, иммунная система, цитокины, аутоантителаАннотация Статья посвящена анализу литературных данных по вопросу иммунной системы и эндометриоза. Рассмотрены особенности иммунной системы, а также механизмы развития эндометриоза при дисфункции иммунной системы. Цель. Изучить роль иммунной системы в патогенезе эндометриоза. Материал и методы. Для анализа литературы проводился поиск информации касательно данной проблемы глубиной до 10 лет в PubMed/MEDLINE, PMC, Web of Sсiеnce. Для поиска использовали следующие термины по отдельности или в комбинации: «генитальный эндометриоз», «иммунная система», «цитокины», «аутоантитела». Критерием поиска были ключевые исследования, связанные с генитальным эндометриозом и иммунной системой: метаанализы, оригинальные исследования, ретроспективные и когортные исследования. Результаты и обсуждение. Необходимо улучшить понимание потенциального происхождения общей иммунопатофизиологии эндометриоза, чтобы определить терапевтические целевые области, которые могут позволить облегчение или, в конечном счете, предотвращение этого заболевания. Иммунологические маркеры в данном аспекте имеют определенные перспективы. Выводы. Хотя роль цитокинов в развитии эндометриоза определена, она недостаточно изучена. В связи с этим трудно четко определить, как они влияют на патогенез эндометриоза. Для того, чтобы лучше понять, необходимы дополнительные исследования, чтобы улучшить современные подходы к диагностике и лечению. Библиографические ссылки Tao Zhang, Caterina De Carolis, Gene Chi, Wai Man, Chi Chiu Wang. The link between immunity, autoimmunity and endometriosis: a literature update. Autoimmun Rev. October 2018;17(10):945-955. DOI: 10.1016/j.autrev.2018.03.017. Herreros-Villanueva M., Chen Ch-Ch., Tsai E-M., Er T-K. Endometriosis-associated ovarian cancer: What have we learned so far? 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