Tumor markers in endometriosis

Abrão MS, Maurício Simões Abrão, M S Abrão, Sérgio Podgaec, S Podgaec, Pinotti JA, J. A. Pinotti, R M de Oliveira, de Oliveira RM
International Journal of Gynecology & Obstetrics · 1999 · vol. 66(1) , pp. 19–22 · doi:10.1016/s0020-7292(99)00046-6 · PMID:10458545 · W2076044586
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This study found that CA 125 concentrations were altered in women with pelvic endometriosis, suggesting it is the only important marker for diagnosing stages III/IV.

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Abstract

OBJECTIVES: The objective of the present study was to determine the concentrations of CA 125, CA 15-3, CA 19-9, carcioembryogenic antigen (CEA), alpha-fetoprotein (AFP) and beta-2 microglobulin (B2MG) in patients with pelvic endometriosis. METHOD: Fifty women were divided into two groups: group A (control) had no endometriosis or other diseases, and group B consisted of 35 women with pelvic endometriosis. All women were submitted to serum determination of CA 125, CA 15-3, CA 19-9, CEA, AFP and B2MG. Samples were collected during the menstrual cycle and 1 week later. RESULTS: Mean CA 125 concentrations were altered in patients with endometriosis, but all 50 patients studied presented normal CEA, AFP and B2MG concentrations. Small variations detected in CA 19-9 and CA 15-3 had no statistical significance. CONCLUSION: CA 125 is the only important marker in the diagnosis of stages III/IV of endometriosis, especially when blood samples for its determination are obtained during the first 3 days of the menstrual cycle.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers, Tumor Endometriosis Biomarkers, Tumor CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Endometriosis Female Humans Pelvis Severity of Illness Index

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (12)

Cited by (43)

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