Endometriosis- A Systemic Disease? A Biochemical Investigation.

Kathleen M King
In: http://www.iol.ie/~kingflanagan/ka/endoproject/endokk.pdf · 2001 · W2182816162
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This study investigated immune markers and CA 125 in women with and without endometriosis, finding no significant differences except for CA 125 and basophil levels.

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Abstract

Background Endometriosis is a major cause of infertility and chronic pain. Women with endometriosis may have chronic immune activation due to the presence of endometrial deposits. The objective of this study was to determine whether women with endometriosis display evidence of an altered immune system and to seek evidence for a diagnostic biochemical profile. From this it may be evident that endometriosis is indeed a systemic disease, with associated symptoms that are not necessarily gynaecological. Methods Thirty-four women living in the North Western Health Board area were recruited to take part in the study. Endometriosis group (13) control group (21). All women completed a questionnaire about menstrual history and lifestyle factors. Blood was collected for analysis of antinuclear antibodies, anticardiolipin antibodies, CA 125 and other markers of inflammation. Results With exception to CA125 and basophil levels, no marked statistically significant differences were found between the blood profiles of both study groups. Questionnaire data correlated with previous literature findings on endometriosis. Conclusions This study should be carried out with multi regional participation to ensure a larger sample number. The diagnosis rate of endometriosis in the North Western region appears to be lower that the estimated 10% of the female population.

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endometriosisinfertility

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