Endometriosis-Associated Ovarian Cancer

Amilcar Barreta, Barreta A, Luis Sarian, Luı́s Otávio Sarian, Amanda Canato Ferracini, Ferracini AC, Larissa Eloy, Eloy L, Angelo Borsarelli Carvalho Brito, Liliana de Angelo Andrade, de Angelo Andrade L, Sophie Derchain
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2018 · vol. 28(7) , pp. 1251–1257 · doi:10.1097/igc.0000000000001317 · PMID:30142123 · W2888557989
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper examines the relationship between endometriosis and ovarian cancer, specifically investigating the types of ovarian cancer most strongly associated with endometriosis.

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Abstract

ObjectiveThe aim of this study was to analyze and compare the clinicopathologic features and prognosis of clear cell ovarian carcinoma (CCOC) and endometrioid ovarian carcinoma (EOC) associated or not with endometriosis.MethodsThis was a reconstituted cohort study from a single-institution Brazilian cancer center approved under review board no. 68150617.7.0000.5404 with 50 patients with CCOC and EOC diagnosed between 1995 and 2016, followed up until 2017. Clinicopathologic characteristics and survival outcomes were analyzed.Result(s)There were 23 women (46%) with CCOC and 27 with EOC (54%); 80% of those women had histologic confirmation of endometriosis; 42% were nulliparous, and 42% were premenopausal; and cancer antigen 125 was elevated in both International Federation of Gynecology and Obstetrics stages I-II disease (mean, 614.7 Ui/mL; range, 3-6030 Ui/mL) or International Federation of Gynecology and Obstetrics stages III-IV disease (mean, 2361.2 Ui/mL; range, 8-12771 Ui/mL). Women with EOC were 7 years younger than those with CCOC. When associated with endometriosis, CCOCs were more likely diagnosed at earlier stages. Endometrioid ovarian carcinoma and CCOC at initial stage and EOC at advanced stage share similar good prognosis. Univariate analysis showed that CCOC not associated with endometriosis has worse overall survival (OS). However, multivariate analysis showed that only abnormally elevated levels of cancer antigen 125 and advanced stage at diagnosis were significantly associated with reduced progression-free survival. Tumor stage remains the only prognostic factor for OS.ConclusionsThe presence of coexisting endometriosis did not change the prognosis of EOC but was associated with better OS in patients with CCOC. Patients with CCOC and EOC at initial stages and EOC at advanced stages have a good prognosis; however, CCOC at advanced stages had a sooner recurrence and shorter OS.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cohort Studies Endometriosis Endometriosis Female Humans Middle Aged Neoplasm Recurrence, Local Neoplasm Recurrence, Local Ovarian Neoplasms Ovarian Neoplasms Prognosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (21)

Source provenance

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License: CC0 · commercial use OK