Endometriosis-associated Ovarian Cancer: A Distinct Clinical Entity?

Valentina E Bounous, Valentina Elisabetta Bounous, Annamaria Ferrero, Luca Fuso, Nicoletta Ravarino, Marcello Ceccaroni, Guido Menato, Nicoletta Biglia
Anticancer research · 2016 · vol. 36(7) , pp. 3445–9 · PMID:27354606 · W2472302669
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Abstract

AIM: The aim of the study was to evaluate the incidence of endometriosis-associated ovarian cancer (EAOC) and compare clinicopathological characteristics and overall survival (OS) between patients with EAOC and those with ovarian cancer not associated with endometriosis. PATIENTS AND METHODS: We identified EAOC among 203 patients with invasive epithelial ovarian cancer who underwent complete surgery at our Institution from January 2004 to March 2014. RESULTS: EAOC was present in 45 patients. EAOC was significantly more frequently diagnosed at an earlier stage of disease (p=0.038). At a median follow-up time of 32 months, OS among patients with EAOC was significantly longer (p=0.039). However, stratifying by stage, the OS advantage of EAOC was not significant. At multivariate analysis, only stage was an independent prognostic factor for OS (hazard ratio=5.7; 95% confidence interval=1.8-18.6; p=0.003). CONCLUSION: EAOC incidence was 22.2%. EAOC appears to be diagnosed at an earlier stage and confers a better OS. However, stratifying by stage, the advantage in survival of EAOC disappears.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasms, Glandular and Epithelial Ovarian Neoplasms Aged Age of Onset Endometriosis Female Humans Incidence Kaplan-Meier Estimate Middle Aged Neoplasms, Glandular and Epithelial Ovarian Neoplasms Prognosis Proportional Hazards Models Retrospective Studies

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