Endometriosis-associated Ovarian Cancer: A Distinct Clinical Entity?

Bounous VE, Valentina E Bounous, Valentina Elisabetta Bounous, Annamaria Ferrero, Ferrero A, Fuso L, Luca Fuso, Ravarino N, Nicoletta Ravarino, Marcello Ceccaroni, Ceccaroni M, Guido Menato, Menato G, Nicoletta Biglia
Anticancer research · 2016 · vol. 36(7) , pp. 3445–9 · PMID:27354606 · W2472302669
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This study evaluated 203 ovarian cancer patients, finding endometriosis-associated cases were diagnosed earlier and showed better overall survival, though this survival advantage diminished when stratified by stage.

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Abstract

AIM: The aim of the study was to evaluate the incidence of endometriosis-associated ovarian cancer (EAOC) and compare clinicopathological characteristics and overall survival (OS) between patients with EAOC and those with ovarian cancer not associated with endometriosis. PATIENTS AND METHODS: We identified EAOC among 203 patients with invasive epithelial ovarian cancer who underwent complete surgery at our Institution from January 2004 to March 2014. RESULTS: EAOC was present in 45 patients. EAOC was significantly more frequently diagnosed at an earlier stage of disease (p=0.038). At a median follow-up time of 32 months, OS among patients with EAOC was significantly longer (p=0.039). However, stratifying by stage, the OS advantage of EAOC was not significant. At multivariate analysis, only stage was an independent prognostic factor for OS (hazard ratio=5.7; 95% confidence interval=1.8-18.6; p=0.003). CONCLUSION: EAOC incidence was 22.2%. EAOC appears to be diagnosed at an earlier stage and confers a better OS. However, stratifying by stage, the advantage in survival of EAOC disappears.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasms, Glandular and Epithelial Ovarian Neoplasms Aged Aged Age of Onset Age of Onset Endometriosis Endometriosis Female Female Humans Humans Incidence Incidence Kaplan-Meier Estimate Kaplan-Meier Estimate Middle Aged Middle Aged Neoplasms, Glandular and Epithelial

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (18)

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