Endometrioid adenocarcinoma of the ovary and endometriosis

Valenzuela P, P. Valenzuela, P Ramos, Ramos P, Pedro Ramos, S. Redondo, Redondo S, Y. Cabrera, Cabrera Y, Íngrid Álvarez, I Alvarez, Alvarez I, Ruiz A, A Ruiz, Antonio Ruíz
European journal of obstetrics, gynecology, and reproductive biology · 2006 · vol. 134(1) , pp. 83–86 · doi:10.1016/j.ejogrb.2006.06.008 · PMID:16844279 · W2141522280
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This study investigates the association between endometrioid adenocarcinoma of the ovary and endometriosis.

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Abstract

ObjectiveWe present a retrospective analysis of 22 cases of endometrioid ovarian carcinoma, reviewed to identify endometriosis and its malignant transformation.Study designTwenty-two patients with endometrioid ovarian cancer were included in the review. Their clinical and histological data were retrospectively reviewed. The origin of the tumours was considered endometriosis-related when the presence of malignant changes in endometriosis glands leading to endometrioid carcinoma were found.ResultsEndometriosis was detected in three cases (3/22=14%). One of them presented a clearly benign to malignant transformation area. In another patient, the transition zone was abrupt and present in both ovaries. In the third, a pre-menopausal woman, ovarian endometriosis with only focal endometrioid carcinoma was observed. The three of them had a clear-cell carcinoma component. The presence of a clear-cell component was significantly greater in patients with endometriosis than in patients without endometriosis Each patient had a different clinical presentation: increase in abdominal perimeter, post-menopausal vaginal haemorrhage and hypermenorrhea. Preoperative CA 125 levels were avalaible in 15 of the patients (15/22=68%). Endometriosis was found in two of these 15 patients, both with the highest CA 125 measured levels, exceeding 1700 U/ml. In the remaining of the patients, CA 125 value did not exceed 35 U/ml.ConclusionAlthough this association is not very frequent, patients with ovarian endometriosis and a high CA 125 serum level should be managed with special care, regardless of their pre-menopausal or post-menopausal status.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Endometriosis Ovarian Neoplasms CA-125 Antigen CA-125 Antigen Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Endometriosis Female Humans Middle Aged Ovarian Neoplasms Ovarian Neoplasms

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References (28)

Cited by (25)

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