Endometriosis and Endometriosis-Associated Ovarian Cancer (EAOC)
Endometriosis, a prevalent disease affecting over 10% of women, may involve clonal epithelial development and atypical hyperplasia, progressing to neoplasia under hormonal influences.
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This chapter reviews evidence on endometriosis as a gynecologic condition affecting reproductive-age women, highlighting recent genetic findings suggesting endometriosis is clonal in epithelium with development independent of stroma. It discusses how endometrioid tissue may undergo atypical hyperplasia and progress to neoplasia under hormonal influences, drawing parallels to endometrium in the uterine cavity. A key limitation is that the provided text is an overview rather than a single original study, and it does not present new experimental methods or quantitative results within the excerpt. This paper is centrally about endometriosis and endometriosis-associated ovarian cancer, linking clonal epithelial genetics and hormonally influenced endometrioid transformation to endometriosis-associated malignancy.
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References (80)
- Affinity-purified DNA-based mutation profiles of endometriosis-related ovarian neoplasms in Japanese patients via openalex
- Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer via openalex
- Cancer-Associated Mutations in Endometriosis without Cancer via openalex
- Cancer risk after a hospital discharge diagnosis of endometriosis via openalex
- Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis via openalex
- Causes of Infertility as Predictors of Subsequent Cancer Risk via openalex
- Clinical and histologic classification of endometriomas. Implications for a mechanism of pathogenesis. via openalex
- Clinical outcomes of patients with clear cell and endometrioid ovarian cancer arising from endometriosis via openalex
- Clinical Presentation of Endometrioid Epithelial Ovarian Cancer with Concurrent Endometriosis: A Multicenter Retrospective Study via openalex
- Clinicopathological characteristics of ovarian carcinomas associated with endometriosis via openalex
- Comparative immunohistochemical studies of <i>bcl</i>‐2 and p53 proteins in benign and malignant ovarian endometriotic cysts via openalex
- Comparison of clinical outcomes of patients with clear cell and endometrioid ovarian cancer associated with endometriosis to papillary serous carcinoma of the ovary via openalex
- Continuous versus cyclic oral contraceptives after laparoscopic excision of ovarian endometriomas: a systematic review and metaanalysis via openalex
- ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN via openalex
- Endometrioid adenocarcinoma of the ovary and endometriosis via openalex
- Endometriosis and risk of ovarian and endometrial cancers in a large prospective cohort of U.S. nurses via openalex
- Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex
- Endometriosis-Associated Ovarian Cancer via openalex
- Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis via openalex
- Endometriosis-associated ovarian neoplasia via openalex
- EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex
- Hormonal and surgical treatments for endometriosis and risk of epithelial ovarian cancer via openalex
- <i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas via openalex
- Increased Association Between Endometriosis and Endometrial Cancer via openalex
- Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis via openalex
- Integrating modern approaches to pathogenetic concepts of malignant transformation of endometriosis via openalex
- Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? via openalex
- Malignant extraovarian endometriosis: A review via openalex
- Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden via openalex
- New insights in the pathophysiology of ovarian cancer and implications for screening and prevention via openalex
- Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis via openalex
- Ovarian and extraovarian endometriosis-associated cancer via openalex
- Ovarian cancer risk associated with varying causes of infertility via openalex
- Postmenopausal cancer risk after self‐reported endometriosis diagnosis in the Iowa Women's Health Study via openalex
- Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills via openalex
- Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis via openalex
- Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan via openalex
- Stage I ovarian carcinoma: different clinical pathologic patterns via openalex
- The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions via openalex
- The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis via openalex
- The relationship of endometriosis and ovarian malignancy: a review via openalex
- The risk of cancer and the role of parity among women with endometriosis via openalex
- Unraveling the two entities of endometrioid ovarian cancer: A single center clinical experience via openalex
- W6675344820 via openalex
- W1546101705 via openalex
- W1817833980 via openalex
- W1961246616 via openalex
- W1965392734 via openalex
- W1998594662 via openalex
- W2000311445 via openalex
- W2000590092 via openalex
- W2009971333 via openalex
- W2011669199 via openalex
- W2025423482 via openalex
- W2040588648 via openalex
- W2042051912 via openalex
- W2042394954 via openalex
- W2053309322 via openalex
- W2074895699 via openalex
- W2088293537 via openalex
- W2090702820 via openalex
- W2091906134 via openalex
- W2098427446 via openalex
- W2105580481 via openalex
- W2110956488 via openalex
- W2119529166 via openalex
- W2125681453 via openalex
- W2146239695 via openalex
- W2170365653 via openalex
- W2174510671 via openalex
- W2270264837 via openalex
- W2317262711 via openalex
- W2332332145 via openalex
- W2335169530 via openalex
- W2469265662 via openalex
- W2593905043 via openalex
- W2613882823 via openalex
- W2904061041 via openalex
- W2907139891 via openalex
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Cited by (12)
- Spatiotemporal Evolutionary Mechanisms and Translational Research Progress in the Malignant Transformation of Endometriosis: A Comprehensive Review 2026
- Predictive value of MR imaging IVIM and T2 mapping in malignant transformation of endometriosis 2025
- Rare Isolated Peritoneal Implant of a Grade 1 Endometrioid Adenocarcinoma in a 20 Year Old- Workup and Management Conundrums: A Case Report 2025
- Research progress on correlative prediction factors and prediction models of endometriosis associated ovarian carcinoma 2024
- Research Progress and Treatment Status of Endometriosis-Related Ovarian Cancer 2024
- Identification and Validation of Prognostic Markers for Endometriosis-Associated Ovarian Cancer 2024
- Pathophysiology and Clinical Implications of Ovarian Endometriomas 2024
- Rare but Still There: A Scoping Review on Endometriosis-Associated Ovarian Cancer 2024
- The Biological Characteristics of Eutopic and Ectopic EndometrialProgenitor Cells in Endometriosis 2023
- Endometriosis and gynaecological cancers: molecular insights behind a complex machinery 2021
- Differentiation between endometriosis-associated ovarian cancers and non- endometriosis-associated ovarian cancers based on magnetic resonance imaging 2021
- The relation between endometrioma and ovarian cancer 2021
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