Explosive rise of serum CA 125 following the rupture of ovarian endometrioma
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Abstract
Serum CA 125 concentration is seldom >100 IU/ml in endometriosis. We report a patient with ruptured endometrioma presenting with a very high CA 125 concentration, 9300 IU/ml. Elimination of endometriosis was followed by a sharp decrease in serum CA 125. We conclude that some of the CA 125 molecules from the ruptured endometriotic cyst may be transferred through the peritoneum, thereby increasing serum CA 125 concentration. The associated inflammatory reaction of the mesothelial cells of the peritoneum was probably the most important contributor to this phenomenon, as mesothelial cells are an important source of CA 125.
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Cited by (32)
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- Enhancing endometrioma management: Diagnostic biomarkers and predictive outcomes in Ruptured vs. Non-Ruptured cases 2024
- Elevated CA 125 in a CASE of Leaking Endometrioma 2018
- Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report 2018
- Spontaneously Ruptured Endometriotic Cysts-A Case Report 2016
- Elevation of plasma D-dimer levels associated with rupture of ovarian endometriotic cysts 2015
- Correlation between ovarian chocolate cyst and serum carbohydrate antigen 125 level and the effect of ultrasound‐guided interventional sclerotherapy on serum carbohydrate antigen 125 level 2014
- Secondary Mullerian System 2013
- Acute Abdomen caused by Intracystic Hemorrhage into an Ovarian Endometrioma: Case Report 2013
- Retrospective evaluation of tumor markers in ovarian mature cystic teratoma and ovarian endometrioma 2012
- Extremely elevated serum CA125 and CA19-9 levels following the rupture of ovarian endometrioma: a case report 2012
- Ruptured Endometrial Cysts as a Rare Cause of Acute Pelvic Pain 2011
- Relation of high CA125 and CA19-9 levels with recent rupture of endometrioma 2011
- CT Imaging Findings of Ruptured Ovarian Endometriotic Cysts: Emphasis on the Differential Diagnosis with Ruptured Ovarian Functional Cysts 2011
- Ruptured Endometrioma Presenting as Acute Abdomen with Highly Raised Serum CA-125 Levels: A Case Report 2011
- Feasibility study of laparoscopic surgery for ovarian endometrioma rupture 2010
- Highly elevated serum CA-125 levels in patients with non-malignant gynecological diseases 2010
- Spontaneously Ruptured Endometrioma Associated with Endometrioid Adenocarcinoma: MR Findings 2010
- Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values 2009
- Massive peritoneal fluid and markedly elevated serum CA125 and CA19‐9 levels associated with an ovarian endometrioma 2009
- Elevation of serum CA 125 and D-dimer levels associated with rupture of ovarian endometrioma 2007
- Transición entre endometriosis y carcinoma endometrioide de ovario 2007
- Extremely elevated serum CA-125 level as a result of unruptured unilateral endometrioma: the highest value reported 2007
- Elevation of Serum CA 125 and D-Dimer Levels associated with Rupture of Ovarian Endometrioma 2007
- Endometrioid adenocarcinoma of the ovary and endometriosis 2006
- High level of CA 125 due to large endometrioma. 2004
- Acute elevation of plasma D-dimer levels associated with rupture of an ovarian endometriotic cyst: Case report 2003
- Unusually elevated serum carbohydrate antigen 125 (CA125) and CA19‐9 levels as a result of unruptured bilateral endometrioma 2003
- Elevated serum CA 125 and CA 19-9 due to spontaneous rupture of endometrioma [Eur J Obstet Gynecol Reprod Biol 2002;105:75–6] 2003
- Endometriosis: A Wide Variety of Imaging Features 2002
- Ovarian cancer in a woman previously diagnosed with endometriosis and an extremely high serum CA-125 level. 2001
- Severe pelvic adhesions following attempted ultrasound-guided drainage of bilateral ovarian endometriomas: Case report 1999
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