High level of CA 125 due to large endometrioma.

Phupong V, Vorapong Phupong, Chen O, Orawan Chen, Pornthip Ultchaswadi, Ultchaswadi P
Journal of the Medical Association of Thailand = Chotmaihet thangphaet · 2004 · vol. 87(9) , pp. 1108–11 · PMID:15516014 · W2152632545
article OA: closed CC0 ⤵ 5 in-corpus citations
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This case report details a 45-year-old woman with a large ovarian endometrioma and elevated CA 125 levels, demonstrating that high CA 125 can occur in benign gynecological conditions.

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Abstract

BACKGROUND: CA 125 is a tumor-associated antigen. Its high levels are usually associated with ovarian malignancies, whereas smaller increases in the levels were associated with benign gynecologic conditions. The authors report a high level of CA 125 in a case of large ovarian endometrioma. CASE REPORT: A 45-year-old nulliparous Thai woman, presented with an increase of her abdominal girth for 7 months. Transabdominal ultrasonogram demonstrated a large ovarian cyst and multiple small leiomyoma uteri, and serum CA 125 level was 1,006 U/ml. The preoperative diagnosis was ovarian cancer with leiomyoma uteri. Exploratory laparotomy was performed. There were a large right ovarian endometrioma, small left ovarian endometrioma and multiple small leiomyoma. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed and histopathology confirmed the diagnosis of endometrioma and leiomyoma. The serum CA 125 level declined to non-detectable at the 4th week. She was well at discharge and throughout her 4th week follow-up period CONCLUSION: Although a very high level of CA 125 is associated with a malignant process, it can also be found in benign conditions such as a large endometrioma. The case emphasizes the association of high levels of CA 125 with benign gynecologic conditions.

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Condition tags

endometriosisendometrioma

MeSH descriptors

CA-125 Antigen Endometriosis Ovarian Diseases CA-125 Antigen Endometriosis Endometriosis Endometriosis Female Humans Hysterectomy Middle Aged Ovarian Diseases Ovarian Diseases Ovarian Diseases Ultrasonography

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