Benign gynecologic conditions associated with a CA-125 level > 1,000 U/mL. A case report.
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A high CA-125 level (>1,000 U/mL) in a patient with dysmenorrhea was associated with benign cystic adenomyosis and uterine endometriosis.
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Abstract
CA-125 was initially investigated as a marker of ovarian cancer. However, various studies have noted that it can be minimally elevated in benign conditions.A case of CA-125 > 1,000 U/mL was associated with benign gynecologic conditions. A 37-year-old woman with a history of endometriosis and premature ovarian failure underwent hormonal therapy for donor in vitro fertilization. After an unsuccessful cycle, severe dysmenorrhea developed. Investigation revealed a CA-125 level of 1,036 U/mL and a uterine mass. On exploratory laparotomy, cystic adenomyosis and uterine endometriosis was found. After excision of these areas, the CA-125 levels returned to normal. In this case, cystic adenomyosis and endometriosis of the uterine serosa were responsible for the elevated CA-125 level.Very high levels of CA-125 are not always associated with a malignant process.
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Cited by (9)
- Uterine adenomyotic cyst with markedly elevated serum CA19‑9 and CA125 levels: A case report 2022
- Extremely elevated serum CA125 and CA19-9 levels following the rupture of ovarian endometrioma: a case report 2012
- Adenomyosis With Extremely Elevated CA 125 Levels 2009
- Évolutions physiopathologiques, diagnostiques et thérapeutiques dans la prise en charge de l’adénomyose : revue de la littérature 2004
- Entstehung und Pathogenese 2004
- High level of CA 125 due to large endometrioma. 2004
- Extremely elevated CA 125 level due to an unruptured large endometrioma 2003
- Ovarian cancer in a woman previously diagnosed with endometriosis and an extremely high serum CA-125 level. 2001
- Extremely Elevated Serum CA125 Due To Endometriosis 1999
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