Abnormally High Values of CA 125 and CA 19-9 in Women with Benign Tumors

H Nagata, Hiroko Nagata, K Takahashi, Kentaro Takahashi, Y Yamane, Yoshio Yamane, Kazuo Yoshino, K Yoshino, Toshihiko Shibukawa, T Shibukawa, Manabu Kitao, M Kitao
Gynecologic and obstetric investigation · 2010 · vol. 28(3) , pp. 165–168 · doi:10.1159/000293559 · PMID:2680806 · W2092169939
article OA: closed CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case series describes five women with benign ovarian tumors (endometriosis or dermoid cyst) who presented with abnormally high CA 125 and/or CA 19-9 levels, complicating preoperative diagnosis.

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Abstract

Tumor markers have proved to be generally useful for diagnosing and monitoring malignancy. In contrast, high levels of tumor markers disturb us for differing benign disease from malignancy. We had 5 cases with benign disease who showed high values of tumor markers (CA 125 and CA 19-9). In this report, we illustrated 3 patients with endometriosis who showed high values of CA 125 and 2 patients with dermoid cyst who showed high values of CA 19-9. It was impossible to rule out malignant disease in all cases preoperatively. In diagnosing ovarian tumors, bimanual examination, ultrasound, CT scan and tumor markers should all be considered.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Dermoid Cyst Endometriosis Ovarian Cysts Ovarian Neoplasms Adult Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Dermoid Cyst Diagnosis, Differential Endometriosis False Positive Reactions Female Humans Middle Aged Ovarian Cysts Ovarian Neoplasms Ultrasonography

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (6)

Source provenance

europepmc
last seen: 2026-06-19T06:14:56.452680+00:00
openalex
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pubmed
last seen: 2026-05-13T22:09:15.954262+00:00
License: CC0 · commercial use OK