Elevation of serum CA 125 and D-dimer levels associated with rupture of ovarian endometrioma

Peter Uharček, P Uharcek, M Mlyncek, M Mlynček, J Ravinger
The International journal of biological markers · 2007 · vol. 22(3) , pp. 203–205 · doi:10.5301/jbm.2008.5668 · PMID:17922464 · W16056277
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Rupture of a large ovarian endometrioma caused elevated serum CA 125 and D-dimer levels, mimicking malignancy and indicating induced coagulation reactions.

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Abstract

BACKGROUND: Patients with endometriosis rarely have a serum CA 125 concentration >100 IU/mL. A raised plasma level of D-dimer indicates active fibrinolysis, either secondary to clot formation or primarily activated. This condition is seldom diagnosed in patients with endometriosis. CASE REPORT: A 53-year-old woman was referred to our institution for acute abdominal pain. Laparoscopic surgery revealed a large ovarian cyst with rupture on the left side. Preoperative laboratory tests detected high serum CA 125 and D-dimer levels. Adnexectomy was performed, resulting in a sharp decrease in serum CA 125 and D-dimer concentration. We describe the clinical course of the patient. CONCLUSION: Rupture of a large ovarian endometrioma can lead to a high serum concentration of CA 125, a condition which, in addition to the detected pelvic mass, may mimic a malignant process. The increased D-dimer plasma level indicated that a ruptured endometriotic cyst can induce coagulation reactions.

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Condition tags

endometriosisendometrioma

MeSH descriptors

CA-125 Antigen Endometriosis Fibrin Fibrinogen Degradation Products Ovarian Cysts CA-125 Antigen Diagnosis, Differential Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Fibrin Fibrinogen Degradation Products Gynecologic Surgical Procedures Humans Laparoscopy Middle Aged Ovarian Cysts Ovarian Cysts

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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