Elevation of serum CA 125 and D-dimer levels associated with rupture of ovarian endometrioma

Uharcek P, Peter Uharček, P Uharcek, M Mlynček, Mlyncek M, M Mlyncek, Ravinger J, J. Ravinger
The International journal of biological markers · 2007 · vol. 22(3) , pp. 203–205 · doi:10.5301/jbm.2008.5668 · PMID:17922464 · W16056277
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Rupture of a large ovarian endometrioma caused elevated serum CA 125 and D-dimer levels, mimicking malignancy and indicating induced coagulation reactions.

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Abstract

BACKGROUND: Patients with endometriosis rarely have a serum CA 125 concentration >100 IU/mL. A raised plasma level of D-dimer indicates active fibrinolysis, either secondary to clot formation or primarily activated. This condition is seldom diagnosed in patients with endometriosis. CASE REPORT: A 53-year-old woman was referred to our institution for acute abdominal pain. Laparoscopic surgery revealed a large ovarian cyst with rupture on the left side. Preoperative laboratory tests detected high serum CA 125 and D-dimer levels. Adnexectomy was performed, resulting in a sharp decrease in serum CA 125 and D-dimer concentration. We describe the clinical course of the patient. CONCLUSION: Rupture of a large ovarian endometrioma can lead to a high serum concentration of CA 125, a condition which, in addition to the detected pelvic mass, may mimic a malignant process. The increased D-dimer plasma level indicated that a ruptured endometriotic cyst can induce coagulation reactions.

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Condition tags

endometriosisendometrioma

MeSH descriptors

CA-125 Antigen Endometriosis Fibrin Fibrinogen Degradation Products Ovarian Cysts CA-125 Antigen CA-125 Antigen Diagnosis, Differential Diagnosis, Differential Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Fibrin Fibrinogen Degradation Products Fibrin Fibrinogen Degradation Products Gynecologic Surgical Procedures

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (16)

Cited by (6)

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