Diagnostic value of serum D‐dimer,CA125, and neutrophil‐to‐lymphocyte ratio in differentiating ovarian cancer and endometriosis

Lifeng Chen, Wang X, Xinyan Wang, Jing Shu, Shu J, Sheng Xu, Xu S, Wu Q, Qing Wu, Yan Yu, Yu Y
International Journal of Gynecology & Obstetrics · 2019 · vol. 147(2) , pp. 212–218 · doi:10.1002/ijgo.12949 · PMID:31469423 · W2971163891
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Serum D-dimer, CA125, and neutrophil-to-lymphocyte ratio demonstrated diagnostic value in differentiating ovarian cancer from endometriosis, with their combined measurement showing high sensitivity and specificity.

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Abstract

OBJECTIVE: To assess the utility of hematologic, inflammatory, and immunologic biomarkers for differentiating between ovarian cancer and endometriosis. METHODS: Data were retrospectively reviewed from women diagnosed with ovarian cancer and endometriosis after ovarian cyst surgery in Zhejiang, China, 2014-2016. Serologic and hematologic biomarkers, including white blood cell count, lymphocyte count, neutrophil count, red blood cell count, hemoglobin, platelets, and D-dimer, albumin, globulin, cancer antigen 125 (CA125) and CA199 serum levels recorded pre-operatively were assessed by ROC curve and logistic regression analysis. RESULTS: Overall, 49 women were diagnosed with ovarian cancer and 192 with endometriosis. For predicting ovarian cancer, the area under the curve (AUC) was 0.96 (95% confidence interval [CI], 0.94-0.99); sensitivity, 93.2%; specificity, 87.5%) for log(D-dimer), 0.95 (95% CI, 0.91-0.98; sensitivity, 81.3%; specificity, 96.3%) for log(CA125), and 0.92 (95% CI, 0.86-0.98; sensitivity, 92.6%; specificity, 79.2%) for neutrophil-to-lymphocyte ratio (NLR). The AUC for the combination of D-dimer, NLR, and CA125 was 0.96 (95% CI, 0.94-0.99; sensitivity, 91.6%; specificity, 89.6%). CONCLUSION: Serum D-dimer, NLR, and CA125 were found to be potential diagnostic factors for ovarian cancer. Combined measurement of D-dimer, NLR, and CA125 might offer a convenient screening method.

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Condition tags

endometriosis

MeSH descriptors

CA-125 Antigen Carcinoma, Ovarian Epithelial Fibrin Fibrinogen Degradation Products Lymphocytes Neutrophils Ovarian Neoplasms Adult Biomarkers, Tumor Biomarkers, Tumor CA-125 Antigen Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial China China Diagnosis, Differential Endometriosis Endometriosis Endometriosis Endometriosis

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