Diagnostic value of serum D-dimer, CA125, and neutrophil-to-lymphocyte ratio in differentiating ovarian cancer and endometriosis

Lifeng Chen, Wang X, Xinyan Wang, Jing Shu, Shu J, Sheng Xu, Xu S, Wu Q, Qing Wu, Yan Yu, Yu Y
International Journal of Gynecology & Obstetrics · 2019 · vol. 147(2) , pp. 212–218 · doi:10.1002/ijgo.12949 · PMID:31469423 · W2971163891
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Serum D-dimer, CA125, and neutrophil-to-lymphocyte ratio demonstrated diagnostic value in differentiating ovarian cancer from endometriosis, with their combined measurement showing high sensitivity and specificity.

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Abstract

OBJECTIVE: To assess the utility of hematologic, inflammatory, and immunologic biomarkers for differentiating between ovarian cancer and endometriosis. METHODS: Data were retrospectively reviewed from women diagnosed with ovarian cancer and endometriosis after ovarian cyst surgery in Zhejiang, China, 2014-2016. Serologic and hematologic biomarkers, including white blood cell count, lymphocyte count, neutrophil count, red blood cell count, hemoglobin, platelets, and D-dimer, albumin, globulin, cancer antigen 125 (CA125) and CA199 serum levels recorded pre-operatively were assessed by ROC curve and logistic regression analysis. RESULTS: Overall, 49 women were diagnosed with ovarian cancer and 192 with endometriosis. For predicting ovarian cancer, the area under the curve (AUC) was 0.96 (95% confidence interval [CI], 0.94-0.99); sensitivity, 93.2%; specificity, 87.5%) for log(D-dimer), 0.95 (95% CI, 0.91-0.98; sensitivity, 81.3%; specificity, 96.3%) for log(CA125), and 0.92 (95% CI, 0.86-0.98; sensitivity, 92.6%; specificity, 79.2%) for neutrophil-to-lymphocyte ratio (NLR). The AUC for the combination of D-dimer, NLR, and CA125 was 0.96 (95% CI, 0.94-0.99; sensitivity, 91.6%; specificity, 89.6%). CONCLUSION: Serum D-dimer, NLR, and CA125 were found to be potential diagnostic factors for ovarian cancer. Combined measurement of D-dimer, NLR, and CA125 might offer a convenient screening method.

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Condition tags

endometriosis

MeSH descriptors

CA-125 Antigen Carcinoma, Ovarian Epithelial Fibrin Fibrinogen Degradation Products Lymphocytes Neutrophils Ovarian Neoplasms Adult Adult Biomarkers, Tumor Biomarkers, Tumor Biomarkers, Tumor CA-125 Antigen CA-125 Antigen Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial China China China

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References (29)

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