Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis

H N Ho, Hong‐Nerng Ho, M Y Wu, Ming‐Yih Wu, Shee‐Uan Chen, S U Chen, Kuang‐Han Chao, K H Chao, C D Chen, Chin‐Der Chen, Y S Yang, Yu‐Shih Yang
Human Reproduction · 1997 · vol. 12(12) , pp. 2810–2815 · doi:10.1093/humrep/12.12.2810 · PMID:9455858 · W2154697543
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Peritoneal total antioxidant status and nitric oxide metabolites did not differ between women with endometriosis and fertile controls, nor were they related to CA 125, estrogen, or progesterone levels.

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Abstract

To explore the role of nitric oxide (NO) and oxidative stress in the pathogenesis of adhesion formation and in endometriosis-associated infertility, we examined the peritoneal total antioxidant status (TAS) and the concentrations of products of NO metabolism in women with endometriosis (early stage, n 12; advanced stage, n 12) and in fertile women without endometriosis (n 10). Peritoneal CA 125 and oestrogen and progesterone concentrations were also measured to examine their contributions to TAS and the production of NO. We failed to demonstrate any significant difference in TAS and in the products of NO metabolism in peritoneal fluids among women with early and advanced stages of endometriosis compared with fertile women without endometriosis during the early follicular phase. TAS and the concentration of the products of NO metabolism were not related to concentrations of CA 125, oestrogen or progesterone. The concentration of CA 125 in serum, but not in peritoneal fluid, was positively correlated with the severity of endometriosis. The volume of peritoneal fluid and the progesterone concentration were significantly increased in the group with advanced endometriosis. TAS and the concentration of the products of NO metabolism did not increase in peritoneal fluids from women with endometriosis during the early follicular phase. Their role in the pathophysiology of endometriosis needs to be explored further. Key words: antioxidants/CA 125/endometriosis/nitric oxide/ peritoneal fluid -), hydrogen peroxide (H 2 O 2 ) and singlet oxygen ( 1 O 2 ). Free radicals formed in the body can initiate a series of reactions which continue until the free radicals are removed, following reactions with other free radicals or, more importantly, by the actions of the antioxidant system. Some authors have suggested that antioxidants protect against endometriosis (Portz et al., 1991), while others have demonstrated no causal relationship with endometriosis (Arumugam and Yip, 1995a,b).

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Condition tags

endometriosisinfertility

MeSH descriptors

Antioxidants Ascitic Fluid Endometriosis Nitric Oxide Antioxidants Ascitic Fluid Ascitic Fluid CA-125 Antigen CA-125 Antigen CA-125 Antigen Endometriosis Female Follicular Phase Humans Nitric Oxide Progesterone Progesterone

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