Leptin and Antioxidant Profile in Infertile Women with Endometriosis

Hussein G. Osman, Abdel Aziz A. El-Refaey, Abdel Aziz F. Abdel Aziz, Ahmed M.A. El-Sokkary, Rasha A. El‐Saeed
In: Journal of Endometriosis · 2010 · vol. 2(3) , pp. 135–143 · doi:10.1177/228402651000200304 · W4250989897
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found higher peritoneal fluid leptin and lower antioxidant capacity in infertile women with endometriosis compared to controls, suggesting a role for peritoneal leptin and oxidative stress in the condition.

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Abstract

Objective To investigate the role of leptin hormone and oxidative stress in the pathogenesis of endometriosis among infertile women. Methods Blood samples and peritoneal fluid were collected from women undergoing laparoscopy. The study group included 24 infertile women with endometriosis, while 14 women with unexplained infertility represented the control group. Leptin hormone levels and three markers of antioxidants, including total antioxidant capacity (TAC), catalase (CAT) enzyme and superoxide dismutase (SOD) enzyme were estimated. Results Peritoneal fluid leptin concentrations were significantly higher in infertile endometriotic women compared with the control group. The levels of TAC, CAT and SOD were significantly lower in both serum and peritoneal fluid of infertile endometriotic women compared with controls. There was no significant difference in serum leptin concentrations between the studied groups. Conclusions Peritoneal leptin and oxidative stress may be an active factor in the pathogenesis and/or progression of endometriosis.

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endometriosisinfertility

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