Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis

Jennifer Mier‐Cabrera, Jennifer Mier-Cabrera, Mercedes Genera‐García, Mercedes Genera-García, Julio de la Jara-Díaz, Otilia Perichart‐Perera, Otilia Perichart-Perera, Felipe Vadillo-Ortega, Felipe Vadillo‐Ortega, César Hernández‐Guerrero, Cesar Hernández-Guerrero
International Journal of Gynecology & Obstetrics · 2007 · vol. 100(3) , pp. 252–256 · doi:10.1016/j.ijgo.2007.08.018 · PMID:18005966 · W2044896222
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Vitamins C and E supplementation reduced oxidative stress markers in women with endometriosis, but did not significantly increase pregnancy rates compared to placebo.

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Abstract

OBJECTIVE: To determine whether vitamins C and E supplementation lowers oxidative stress marker levels and improves pregnancy rate in women with endometriosis. METHODS: Thirty-four women with endometriosis received a bar containing vitamins C and E (343 mg and 84 mg, respectively) or placebo for 6 months. Plasma and peritoneal fluid levels of malondialdehyde (MDA) and lipid hydroperoxides (LOOHs) were measured for all women and compared between the 2 groups. Data were analyzed by the t test or 1-way analysis of variance for parametric data and the Mann-Whitney rank sum test or Kruskall-Wallis test for nonparametric data. The Fisher exact test was used to compare pregnancy rates. RESULTS: After 4 months, the study group had lower levels of MDA and LOOHs than the control group, and the difference became statistically significant in the fourth month for MDA levels and in the sixth month for LOOH levels. The postintervention pregnancy rates were 19% and 12% in the supplementation and placebo groups, respectively, but the difference was not significant. CONCLUSIONS: Vitamins C and E supplementation was associated with a decrease in the concentration of oxidative stress markers in women with endometriosis. The pregnancy rate, however, did not improve during or after the intervention.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Antioxidants Ascorbic Acid Endometriosis Oxidative Stress Vitamin E Adult Antioxidants Antioxidants Ascorbic Acid Ascorbic Acid Biomarkers Biomarkers Double-Blind Method Endometriosis Female Humans Lipid Peroxidation Lipid Peroxidation Oxidative Stress Pregnancy

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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