Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility

Elisa Melo Ferreira, Evandro Maia Ferreira, Vanessa Silvestre Innocenti Giorgi, Giorgi VSI, Jhenifer Kliemchen Rodrigues, Rodrigues JK, Aline Zyman de Andrade, de Andrade AZ, Junior AAJ, Alceu Afonso Jordão Junior, Alceu Afonso Jordão, Paula Andrea Navarro
Reproductive BioMedicine Online · 2019 · vol. 39(5) , pp. 785–794 · doi:10.1016/j.rbmo.2019.06.011 · PMID:31540845 · W2955742610
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper investigates systemic oxidative stress as a potential factor contributing to the development of infertility in women with mild endometriosis.

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Abstract

Research questionDoes systemic oxidative stress occur during the early follicular phase of the menstrual cycle in infertile women with minimal (stage I) or mild (stage II) endometriosis? Are serum oxidative stress markers during the early follicular phase of the menstrual cycle good predictors of successful gestation in these women who undergo ovarian stimulation for intracytoplasmic sperm injection (ICSI)?Materials and methodsA pilot study (prospective case-control study) was conducted in a University Hospital. Serum samples were obtained during the early follicular phase of the natural cycle preceding ovarian stimulation for ICSI of infertile women (with and without stage I and II endometriosis, the latter having male factor infertility). Total hydroperoxides (FOX1), malondialdehyde, advanced oxidation protein products, reduced glutathione, superoxide dismutase, total antioxidant capacity (TAC), 8-hydroxy-2'-deoxyguanosine (8OHdG) and vitamin E were analysed in serum from 35 women with stage I or II endometriosis and 60 control women. The accuracy of oxidative stress markers for predicting clinical pregnancy and live births was determined by receiver operator characteristic curves.ResultsWomen with stage I and II endometriosis showed lower serum 8OHdG concentrations (16.02 ng/ml) compared with the control group (22.08 ng/ml). The best predictor for clinical pregnancy and live births was TAC, whereas FOX1 was the best predictor of clinical pregnancy in the control group.ConclusionsInfertile women with stage I and II endometriosis present systemic oxidative stress during the early follicular phase of the menstrual cycle. Some oxidative stress markers were good predictors of clinical pregnancy and live births after ICSI. Serum TAC was predictive of clinical pregnancy and live births after ICSI in women with stage I or II endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Infertility, Female Oxidative Stress Birth Rate Case-Control Studies Endometriosis Female Fertilization Follicular Fluid Follicular Fluid Humans Infertility, Female Menstrual Cycle Oocytes Oocytes Ovulation Induction Pilot Projects Pregnancy Pregnancy Rate

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