A systematic review and meta-analysis of advanced oxidative protein products levels (AOPP) levels in endometriosis: Association with disease stage and clinical implications
meta-analysis
OA: closed
CC0
⤵ 2 in-corpus citations
AI-generated summary
This systematic review and meta-analysis examined AOPP levels in endometriosis, finding them associated with disease stage and presenting potential clinical implications.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Endometriosis is a common cause of chronic pelvic pain and lacks precise pathophysiological mechanisms. Advanced oxidation protein products (AOPPs), markers of oxidative stress and inflammation, are implicated in pain-related diseases and have been suggested to play a crucial role in endometriosis pathophysiology. We aim to assess the significance of AOPP in endometriosis by analyzing their levels across serum, follicular fluid, peritoneal fluid, and ovarian endometrioma tissue, and their association with different disease stages. A systematic review of articles published up to Nov 2024 examining AOPP levels in endometriosis patients compared to controls was conducted (PROSPERO: CRD42022343714). Using the Newcastle-Ottawa Scale (NOS), the quality and risk of bias of included studies were assessed, and publication bias was evaluated using Egger's and Begg's tests. The analysis 12 studies involving 561 control patients without endometriosis and 670 patients with endometriosis. Compared to controls, elevated AOPP levels were observed in endometriosis patients' serum and peritoneal fluid. Patients with type III/IV endometriosis exhibited higher AOPP levels in serum and plasma compared to control patients, suggesting a potential association with disease severity. The study underscores the potential of AOPP levels as biomarkers for endometriosis severity and proposes them as pharmacological targets for disease management, including pelvic pain treatment.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (46)
- 1H NMR Based Targeted Metabolite Profiling for Understanding the Complex Relationship Connecting Oxidative Stress with Endometriosis via openalex
- 7 Endometriosis and pelvic pain via openalex
- Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis via openalex
- AOPPs induces EMT and fibrosis by activating oxidative stress through ERK/p38 MAPK signaling pathway in endometriosis via openalex
- A potential role of Sirtuin3 and its target enzyme activities in patients with ovarian endometrioma via openalex
- Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients via openalex
- ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis via openalex
- A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1) via openalex
- Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives via openalex
- Biomarkers in endometriosis: challenges and opportunities via openalex
- Blood biomarkers for the non-invasive diagnosis of endometriosis via openalex
- Deep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease via openalex
- Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis via openalex
- Increased concentration of 8-hydroxy-2′-deoxyguanosine in follicular fluid of infertile women with endometriosis via openalex
- Increased Serum Oxidative Stress Markers in Women with Uterine Leiomyoma via openalex
- Is There a Balance in Oxidative-Antioxidant Status in Blood Serum of Patients with Advanced Endometriosis? via openalex
- Oocyte oxidative DNA damage may be involved in minimal/mild endometriosis‐related infertility via openalex
- Pathophysiology, diagnosis, and management of endometriosis via openalex
- Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased via openalex
- Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis via openalex
- Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility via openalex
- The Impact of Controlled Ovarian Stimulation on Serum Oxidative Stress Markers in Infertile Women with Endometriosis Undergoing ICSI via openalex
- W6745616066 via openalex
- W6772402243 via openalex
- W2946423384 via openalex
- W2006230803 via openalex
- W2042641359 via openalex
- W2098923148 via openalex
- W2107328434 via openalex
- W2111376662 via openalex
- W2116475791 via openalex
- W2125435699 via openalex
- W2126574470 via openalex
- W2138118457 via openalex
- W2157823046 via openalex
- W2169205464 via openalex
- W2214531950 via openalex
- W2512604987 via openalex
- W2626866612 via openalex
- W1964435302 via openalex
- W2966841873 via openalex
- W3194685939 via openalex
- W4205272546 via openalex
- W4214754424 via openalex
- W6679274162 via openalex
- W6714839012 via openalex
Cited by (3)
- An ensemble machine learning model based on magnetic resonance imaging features for diagnosing deep infiltrating endometriosis 2026
- Molecular Insights Into Endometriosis for Early Detection and Therapeutic Targets 2026
- Precision Therapeutic and Preventive Molecular Strategies for Endometriosis-Associated Infertility 2025
Source provenance
- europepmc
- last seen: 2026-07-27T06:15:28.040536+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-07-27T06:11:54.727226+00:00
License: CC0
· commercial use OK