Systemic oxidative stress as a possible mechanism underlying the pathogenesis of mild endometriosis-related infertility

Elisa Melo Ferreira, Evandro Maia Ferreira, Vanessa Silvestre Innocenti Giorgi, Giorgi VSI, Jhenifer Kliemchen Rodrigues, Rodrigues JK, Aline Zyman de Andrade, de Andrade AZ, Junior AAJ, Alceu Afonso Jordão Junior, Alceu Afonso Jordão, Paula Andrea Navarro
Reproductive BioMedicine Online · 2019 · vol. 39(5) , pp. 785–794 · doi:10.1016/j.rbmo.2019.06.011 · PMID:31540845 · W2955742610
Observational OA: closed CC0 ⤵ 19 in-corpus citations
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This paper investigates systemic oxidative stress as a potential factor contributing to the development of infertility in women with mild endometriosis.

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Abstract

RESEARCH QUESTION: Does systemic oxidative stress occur during the early follicular phase of the menstrual cycle in infertile women with minimal (stage I) or mild (stage II) endometriosis? Are serum oxidative stress markers during the early follicular phase of the menstrual cycle good predictors of successful gestation in these women who undergo ovarian stimulation for intracytoplasmic sperm injection (ICSI)? MATERIALS AND METHODS: A pilot study (prospective case-control study) was conducted in a University Hospital. Serum samples were obtained during the early follicular phase of the natural cycle preceding ovarian stimulation for ICSI of infertile women (with and without stage I and II endometriosis, the latter having male factor infertility). Total hydroperoxides (FOX1), malondialdehyde, advanced oxidation protein products, reduced glutathione, superoxide dismutase, total antioxidant capacity (TAC), 8-hydroxy-2'-deoxyguanosine (8OHdG) and vitamin E were analysed in serum from 35 women with stage I or II endometriosis and 60 control women. The accuracy of oxidative stress markers for predicting clinical pregnancy and live births was determined by receiver operator characteristic curves. RESULTS: Women with stage I and II endometriosis showed lower serum 8OHdG concentrations (16.02 ng/ml) compared with the control group (22.08 ng/ml). The best predictor for clinical pregnancy and live births was TAC, whereas FOX1 was the best predictor of clinical pregnancy in the control group. CONCLUSIONS: Infertile women with stage I and II endometriosis present systemic oxidative stress during the early follicular phase of the menstrual cycle. Some oxidative stress markers were good predictors of clinical pregnancy and live births after ICSI. Serum TAC was predictive of clinical pregnancy and live births after ICSI in women with stage I or II endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Infertility, Female Oxidative Stress Oxidative Stress Birth Rate Birth Rate Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Fertilization Fertilization Follicular Fluid Follicular Fluid Follicular Fluid Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (19)

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