Estresse oxidativo sistêmico e folicular em mulheres inférteis com endometriose submetidas à injeção intracitoplasmática de espermatozoide

Michele Gomes Da Broi, Felipe Oliveira de Albuquerque, Aline Zyman de Andrade, Alceu Afonso Jordão, Paula Andrea Navarro
In: Reprodução & Climatério · 2014 · vol. 29(3) , pp. 112–122 · doi:10.1016/j.recli.2015.04.005 · W1857512115
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Infertile women with endometriosis undergoing ICSI had higher serum GSH and SOD, lower serum TAC, and higher follicular 8-OHdG and Vitamin E compared to women without endometriosis.

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Abstract

Comparar oito marcadores de estresse oxidativo (EO) no soro e no fluido folicular (FF) de mulheres inférteis com e sem endometriose (E) submetidas à estimulação ovariana controlada (EOC) para injeção intracitoplasmática de espermatozoide (ICSI). Foram coletadas 87 amostras de soro (43 com E e 44 sem E – com fator tubário e/ou masculino) e 61 amostras de FF (29 com E e 32 sem E) no dia da captação oocitária. Hidroperóxidos totais (FOX1), malondialdeído (MDA), produtos avançados de oxidação proteica (AOPP), glutationa (GSH), superóxido dismutase (SOD) e capacidade antioxidante total (CAT) foram determinados por espectrofotometria; vitamina E (Vit E) por cromatografia líquida de alta eficiência; e 8‐hidroxi‐2’‐deoxiguanosina (8 OHdG) por ELISA. Foram observadas maiores concentrações séricas de GSH (220,32 ± 43,2 nmol/g pt) e SOD (677,9 ± 282,21 U/mL), menores concentrações séricas da CAT (0,34 ± 0,17 mEq Trolox/L) e maiores concentrações foliculares de 8 OHdG (23,19 ± 6,8 ng/mL) e Vit E (13,0 ± 5,33 μmol/L) em mulheres inférteis com E comparadas às sem E (193,92 ± 43,25 nmol/g pt, 563,04 ± 169,82 U/mL, 0,46 ± 0,15 mEq Trolox/L, 17,22 ± 5,6 ng/mL e 8,71 ± 2,51 μmol/L, respectivamente). Foi evidenciado EO sistêmico e folicular em pacientes inférteis com E submetidas à EOC para ICSI. Sugerimos que o EO possa estar envolvido na etiopatogênese da infertilidade relacionada à doença The aim of the study was to compare eight oxidative stress (OS) markers in serum and follicular fluid (FF) of infertile women with and without endometriosis (E) undergoing controlled ovarian stimulation (COS) for intracytoplasmic sperm injection (ICSI). Eight‐seven serum samples (43 with E and 44 without E ‐ with male or tubal factor) and 61 FF samples (29 with E and 32 without E) were collected in the day of oocyte retrieval. Total hydroperoxides (FOX1), malondialdehyde (MDA), advanced oxidation protein products (AOPP), glutathione (GSH), superoxide dismutase (SOD) and the total antioxidant capacity (TAC) were determined by spectrophotometry, vitamin E (Vit E) by high performance liquid chromatography, and 8‐hydroxy‐2’–deoxyguanosine (8 OHdG) by ELISA. We observed higher serum concentrations of GSH (220.32 ± 43.2 nmol/g pt) and SOD (677.9 ± 282.21 U/mL), lower serum concentrations of TAC (0.34 ± 0.17 mEq Trolox/L), and higher follicular concentrations of 8 OHdG (23.19 ± 6.8 ng/mL) and Vit E (13.0 ± 5.33 μmol/L) in infertile women with E compared to those without E (193.92 ± 43.25 nmol/g pt, 563.04 ± 169.82 U/mL, 0.46 ± 0.15 mEq Trolox/L, 17.22 ± 5.6 ng/mL and 8.71 ± 2.51 μmol/L, respectively). We evidenced the occurrence of systemic and follicular OS in infertile patients with E undergoing COS for ICSI. We suggest that the OS may be involved in the etiopathogenesis of infertility‐related disease

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endometriosisinfertility

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