Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF

Abhay K. Singh, Singh AK, Chattopadhyay R, Ratna Chattopadhyay, Baidyanath Chakravarty, Chakravarty B, Koel Chaudhury
Reproductive toxicology (Elmsford, N.Y.) · 2013 · vol. 42 , pp. 116–124 · doi:10.1016/j.reprotox.2013.08.005 · PMID:23994512 · W2073542902
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This study investigated oxidative stress markers in follicular fluid from women undergoing IVF, comparing those with endometriosis to women with tubal infertility.

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Abstract

Oxidative stress and trace elements in the oocytes environment is explored in endometriosis and impact on in vitro fertilization (IVF) outcome assessed. Follicular fluid was aspirated at the time of oocyte retrieval from endometriosis (n=200) and tubal infertility (n=140) and the analytes measured using spectroscopy and HPLC. Increased concentration of reactive oxygen species (ROS), nitric oxide (NO), lipid peroxidation (LPO), iron, lead, cadmium and reduced levels of total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), vitamins A, C, E, copper, zinc and selenium was observed compared to tubal infertility. Increased ROS and NO in endometriosis and tubal infertility associated with poor oocytes and embryo quality. Increased levels of ROS, NO, LPO, cadmium and lead were observed in women who did not become pregnant compared to women who did. Intrafollicular zinc levels were higher in women with endometriosis who subsequently became pregnant following IVF.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Follicular Fluid Infertility, Female Metals, Heavy Oxidative Stress Adult Biomarkers Biomarkers Catalase Catalase Embryo Transfer Endometriosis Female Fertilization in Vitro Follicular Fluid Glutathione Peroxidase Glutathione Peroxidase Glutathione Reductase Glutathione Reductase Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (60)

Cited by (50)

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