Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment

Kelton Tremellen, Peter Russell
The Australian & New Zealand journal of obstetrics & gynaecology · 2011 · vol. 51(3) , pp. 280–283 · doi:10.1111/j.1479-828x.2010.01276.x · PMID:21631453 · W1518026669
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This case series identified adenomyosis as a potential cause of recurrent implantation failure in IVF, characterized by macrophage aggregation in endometrial glands, and showed that its inactivation led to successful pregnancies.

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Abstract

Four women, who previously had undergone multiple unsuccessful in vitro fertilisation (IVF) cycles because of failure of implantation of good quality embryos, were identified as having coexisting uterine adenomyosis. Endometrial biopsies showed that adenomyosis was associated with a prominent aggregation of macrophages within the superficial endometrial glands, potentially interfering with embryo implantation. The inactivation of adenomyosis by an ultra-long pituitary downregulation regime promptly resulted in successful pregnancy for all women in this case series.

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Condition tags

mesh:D004715adenomyosis

MeSH descriptors

Embryo Implantation Endometriosis Adult Anti-Inflammatory Agents Anti-Inflammatory Agents Embryo Implantation Endometriosis Endometriosis Female Fertilization in Vitro Fertilization in Vitro Fertilization in Vitro Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Goserelin Goserelin Humans Macrophages Macrophages Macrophages

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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