Defective myometrial spiral artery remodelling as a cause of major obstetrical syndromes in endometriosis and adenomyosis

I Brosens, Brosens I, R Pijnenborg, Pijnenborg R, Robert Pijnenborg, Benagiano G, Giuseppe Benagiano, G Benagiano
Placenta · 2012 · vol. 34(2) , pp. 100–105 · doi:10.1016/j.placenta.2012.11.017 · PMID:23232321 · W2039845234
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This paper investigates how defective spiral artery remodeling in the uterus contributes to major obstetrical syndromes in women with endometriosis and adenomyosis.

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Abstract

Endometriosis and adenomyosis are characterized by the presence of ectopic endometrium, but are also associated with functional and structural changes in the eutopic endometrium and inner myometrium. Alterations in the inner myometrium occurring in women with endometriosis and adenomyosis may be at the root of a defective remodelling of the myometrial spiral arteries from the onset of decidualization and result in vascular resistance and increased risk of defective deep placentation. The association of major obstetrical syndromes and different types of defective remodelling of the myometrial spiral arteries has been well documented. The possibility of a link between both endometriosis and adenomyosis and some major obstetric syndromes remains controversial because of at least two factors: first, changes of the inner myometrium are frequently present in women with endometriosis but the diagnosis requires high-resolution imaging such as magnetic resonance which is not routinely performed and second, patients with endometriosis are frequently subjected to prolonged hormone suppressive therapy. Indeed, there is evidence that pre-treatment with a Gonadotropin Releasing-Hormone analogue can improve the uterine microenvironment and implantation rate following IVF in infertile patients with endometriosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Myometrium Pregnancy Complications Uterine Artery Uterine Artery Abortion, Spontaneous Abortion, Spontaneous Adenomyosis Adenomyosis Adenomyosis Endometriosis Endometriosis Endometriosis Female Humans Infant, Newborn Myometrium Myometrium Myometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (49)

Cited by (50)

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License: CC0 · commercial use OK