Infertilität bei Endometriose und Adenomyose – welche Bedeutung hat die Implantation?

In: Gynäkologische Endokrinologie · 2024 · vol. 22(2) , pp. 118–124 · doi:10.1007/s10304-024-00567-0 · W4394749972
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Endometriosis and adenomyosis are common gynecological diseases associated with subfertility, impaired ovarian function, and frequent miscarriages and implantation disorders.

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The paper discusses infertility in endometriosis and adenomyosis, focusing on whether implantation disorders contribute more than previously assumed. It characterizes endometriosis as commonly associated with subfertility via chronic inflammatory reactions and an altered peritoneal environment that impair ovarian function and oocyte quality, while also noting that miscarriages and implantation disorders occur more frequently. A key caveat is that the question of implantation impairment’s relative importance remains insufficiently answered. This paper is centrally about endometriosis and adenomyosis—specifically the role of implantation in infertility.

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Zusammenfassung Endometriose ist eine der häufigsten gynäkologischen Erkrankungen. Sie ist per se mit dem Risiko der Subfertilität behaftet. Chronisch-entzündliche Reaktionen und ein verändertes peritoneales Milieu beeinträchtigen die Ovarien und die Eizellqualität. Aborte und Implantationsstörungen kommen häufiger vor. Ob die gestörte Implantation eine größere Rolle spielt als bisher angenommen, ist eine noch nicht hinreichend beantwortete Frage. Abstract Endometriosis is one of the most frequent gynecological diseases. It is associated per se with the risk of subfertility. Chronic inflammatory reactions and an altered peritoneal environment impair the ovaries and the quality of oocytes. Miscarriages and implantation disorders are frequent. Whether the impaired implantation plays a more important role than previously assumed is still an insufficiently answered question. Similar content being viewed by others Literatur Pirtea P, de Ziegler D, Ayoubi JM (2021) Effects of endometriosis on assisted reproductive technology: gone with the wind. Fertil Steril 115(2):321–322. https://doi.org/10.1016/j.fertnstert.2020.08.1431 Bishop LA, Gunn J, Jahandideh S, Devine K, Decherney AH, Hill MJ (2021) Endometriosis does not impact live-birth rates in frozen embryo transfers of euploid blastocysts. Fertil Steril 115(2):416–422. https://doi.org/10.1016/j.fertnstert.2020.07.050 Bulun SE (2009) Endometriosis. N Engl J Med 360(3):268–279. https://doi.org/10.1056/NEJMra0804690 Brosens I, Pijnenborg R, Benagiano G (2013) Defective myometrial spiral artery remodelling as a cause of major obstetrical syndromes in endometriosis and adenomyosis. Placenta 34(2):100–105. https://doi.org/10.1016/j.placenta.2012.11.017 Xue Q, Lin Z, Cheng YH, Huang CC, Marsh E, Yin P, Milad MP, Confino E, Reierstad S, Innes J, Bulun SE (2007) Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis. Biol Reprod 77(4):681–687. https://doi.org/10.1095/biolreprod.107.061804 Cheng YH, Yin P, Xue Q, Yilmaz B, Dawson MI, Bulun SE (2008) Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J Clin Endocrinol Metab 93(5):1915–1923. https://doi.org/10.1210/jc.2007-1536 Sanchez AM, Viganò P, Somigliana E, Panina-Bordignon P, Vercellini P, Candiani M (2014) The distinguishing cellular and molecular features of the endometriotic ovarian cyst: from pathophysiology to the potential endometrioma-mediated damage to the ovary. Hum Reprod Update 20(2):217–230. https://doi.org/10.1093/humupd/dmt053 Sanchez AM, Vanni SV, Bartiromo L, Papaleo E, Zilberberg E, Candiani M, Orvieto R, Vigano P (2017) Is the oocyte quality affected by endometriosis ? A review of literature. J Ovarian Res 10:43 Takeuchi A, Koga K, Satake E, Makabe T, Taguchi A, Miyashita M, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Wada-Hiraike O, Fujii T, Osuga Y (2019) Endometriosis triggers excessive activation of primordial follicles via PI3K-PTEN-Akt-Foxo3 pathway. J Clin Endocrinol Metab 104(11):5547–5554. https://doi.org/10.1210/jc.2019-00281 Gomes FM, Navarro PA, de Abreu LG, Ferriani RA, dos Reis RM, de Moura MD (2008) Effect of peritoneal fluid from patients with minimal/mild endometriosis on progesterone release by human granulosa-lutein cells obtained from infertile patients without endometriosis: a pilot study. Eur J Obstet Gynecol Reprod Biol 138(1):60–65. https://doi.org/10.1016/j.ejogrb.2007.12.008 Thombre Kulkarni M, Shafrir A, Farland LV, Terry KL, Whitcomb BW, Eliassen AH, Bertone-Johnson ER, Missmer SA (2022) Association between laparoscopically confirmed endometriosis and risk of early natural menopause. JAMA Netw Open 5(1):e2144391. https://doi.org/10.1001/jamanetworkopen.2021.44391 Dongye H, Ji X, Ma X, Song J, Yan L (2021) The impact of endometriosis on embryo quality in in-vitro fertilization/Intracytoplasmic sperm injection: a systematic review and meta-analysis. Front Med 8:669342. https://doi.org/10.3389/fmed.2021.669342 Díaz I, Navarro J, Blasco L, Simón C, Pellicer A, Remohí J (2000) Impact of stage III–IV endometriosis on recipients of sibling oocytes: matched case-control study. Fertil Steril 74(1):31–34. https://doi.org/10.1016/s0015-0282(00)00570-7 Du YB, Gao MZ, Shi Y, Sun ZG, Wang J (2013) Endocrine and inflammatory factors and endometriosis-associated infertility in assisted reproduction techniques. Arch Gynecol Obstet 287(1):123–130. https://doi.org/10.1007/s00404-012-2567-0 Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y (2019) Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update 25(5):592–632. https://doi.org/10.1093/humupd/dmz012 Wu Y, Halverson G, Basir Z, Strawn E, Yan P, Guo SW (2005) Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol 193(2):371–380. https://doi.org/10.1016/j.ajog.2005.01.034 Pallinger E, Bognar Z, Bogdan A, Csabai T, Abraham H, Szekeres-Bartho J (2018) PIBF+ extracellular vesicles from mouse embryos affect IL-10 production by CD8+ cells. Sci Rep 8(1):4662. https://doi.org/10.1038/s41598-018-23112-z Vallvé-Juanico J, Houshdaran S, Giudice LC (2019) The endometrial immune environment of women with endometriosis. Hum Reprod Update 25(5):564–591. https://doi.org/10.1093/humupd/dmz018 Küpker W, Unveröffentlichte Daten. Flor I, Bullerdiek J (2012) The dark side of a success story: microRNAs of the C19MC cluster in human tumours. J Pathol 227(3):270–274. https://doi.org/10.1002/path.4014 Bullerdiek J, Flor I (2012) Exosome-delivered microRNAs of chromosome 19 microRNA cluster as immunomodulators in pregnancy and tumorigenesis. Mol Cytogenet 5(1):27. https://doi.org/10.1186/1755-8166-5-27 Malnou EC, Umlauf D, Mouysset M, Cavaillé J (2019) Imprinted microRNA gene clusters in the evolution, development, and functions of mammalian placenta. Front Genet 9:706. https://doi.org/10.3389/fgene.2018.00706 Buckberry S, Bianco-Miotto T, Roberts CT (2014) Imprinted and X-linked non-coding RNAs as potential regulators of human placental function. Epigenetics 9(1):81–89. https://doi.org/10.4161/epi.26197 Hromadnikova I, Kotlabova K, Ondrackova M, Kestlerova A, Novotna V, Hympanova L, Doucha J, Krofta L (2013) Circulating C19MC microRNAs in preeclampsia, gestational hypertension, and fetal growth restriction. Mediators Inflamm. https://doi.org/10.1155/2013/186041 Xie L, Sadovsky Y (2016) The function of miR-519d in cell migration, invasion, and proliferation suggests a role in early placentation. Placenta 48:34–37. https://doi.org/10.1016/j.placenta.2016.10.004 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt W. Küpker, J. Bullerdiek und R.E. Felberbaum geben an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Additional information Redaktion Georg Griesinger, Lübeck Wolfgang Küpker, Baden-Baden Hinweis des Verlags Der Verlag bleibt in Hinblick auf geografische Zuordnungen und Gebietsbezeichnungen in veröffentlichten Karten und Institutsadressen neutral. Anteile dieses Artikels wurden publiziert in Küpker W et al. (2024) Endometriose und Infertilität. Gynäkologie 57:131–137. https://doi.org/10.1007/s00129-024-05203-3. QR-Code scannen & Beitrag online lesen Rights and permissions About this article Cite this article Küpker, W., Bullerdiek, J. & Felberbaum, R.E. Infertilität bei Endometriose und Adenomyose – welche Bedeutung hat die Implantation?. Gynäkologische Endokrinologie 22, 118–124 (2024). https://doi.org/10.1007/s10304-024-00567-0 Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10304-024-00567-0 Schlüsselwörter - Endometriose/Pathophysiologie - Chronische Inflammation - Implantationsstörung - Implantationsversagen - Mikro-RNA

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