Clinical Research Progress of Adenomyosis

欣欣 席
In: Advances in Clinical Medicine · 2022 · vol. 12(12) , pp. 11852–11857 · doi:10.12677/acm.2022.12121707 · W4313195306
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This review discusses clinical progress in understanding adenomyosis, a common gynecological disease, noting its unclear pathogenesis and the increasing demand for fertility-preserving treatments.

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This review article examines the current clinical research landscape surrounding adenomyosis, a condition defined by endometrial tissue presence within the uterine myometrium that causes smooth muscle hypertrophy and proliferation. The authors synthesize recent literature to address the disease's unclear pathogenesis, diagnostic challenges using imaging modalities like MRI and ultrasound, and evolving treatment strategies that increasingly prioritize fertility preservation and long-term management over hysterectomy. Key topics covered include the epidemiology of the condition, its association with anxiety and depression, and the comparative efficacy of medical versus surgical interventions such as uterine artery embolization. This paper is centrally about adenomyosis, providing a comprehensive overview of its pathogenesis, diagnosis, and therapeutic approaches in contemporary gynecological practice.

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子宫腺肌病临床研究进展 Clinical Research Progress of Adenomyosis Clinical Research Progress of Adenomyosis DOI: 10.12677/ACM.2022.12121707, PDF, 被引量 作者: 席欣欣, 张林凤, 李 佳*：吉林大学第一医院妇产科，吉林 长春 关键词: 子宫腺肌病；发病机制；治疗；Adenomyosis； Pathogenesis； Treatment 作者: 席欣欣, 张林凤, 李 佳*：吉林大学第一医院妇产科，吉林 长春 关键词: 子宫腺肌病；发病机制；治疗；Adenomyosis； Pathogenesis； Treatment 摘要: 子宫腺肌病(Adenomyosis, AM)是指在子宫肌层中存在子宫内膜组织，并伴有不等程度的肌层平滑肌细胞肥大和增生。AM是一种常见且难治的妇科良性肿瘤性疾病，是导致育龄期女性及围绝经期女性子宫全切的主要原因之一。近年来，生育力保护的理念得到了人们的认可。女性越来越关注子宫的生殖健康，要求子宫腺肌病的治疗长效化。然而，目前AM的发病机制尚不明确。 Abstract: Adenomyosis (AM) refers to the presence of endometrial tissue in the myometrium, accompanied by varying degrees of hypertrophy and proliferation of myometrial smooth muscle cells. AM is a common and refractory gynecological benign tumor disease, which is one of the main reasons for total hysterectomy in women of childbearing age and perimenopause. In recent years, the concept of fertility protection has been recognized by people. Women pay more and more attention to the reproductive health of the uterus and require long-term treatment of adenomyosis. However, the pathogenesis of AM is still unclear. 文章引用：席欣欣, 张林凤, 李佳. 子宫腺肌病临床研究进展[J]. 临床医学进展, 2022, 12(12): 11852-11857. https://doi.org/10.12677/ACM.2022.12121707 | [1] | Zannoni, L., Ambrosio, M., Raimondo, D., et al. (2020) Question Mark Sign and Transvaginal Ultrasound Uterine Ten-derness for the Diagnosis of Adenomyosis: A Prospective Validation. Journal of Ultrasound in Medicine, 39, 1405-1412. [Google Scholar] [CrossRef] [PubMed] | | [2] | Harada, T., Khine, Y.M., Kaponis, A., et al. (2016) The Impact of Adeno-myosis on Women’s Fertility. Obstetrical & Gynecological Survey, 71, 557-568. [Google Scholar] [CrossRef] | | [3] | Vannuccini, S. and Petraglia, F. (2019) Recent Advances in Understanding and Managing Adenomyosis. F1000Research, 8, 283. [Google Scholar] [CrossRef] [PubMed] | | [4] | Raffone, A., Seracchioli, R., Raimondo, D., et al. (2021) Prevalence of Adenomyosis in Endometrial Cancer Patients: A Systematic Review and Meta-Analysis. Archives of Gy-necology and Obstetrics, 303, 47-53. [Google Scholar] [CrossRef] [PubMed] | | [5] | Anna, S.C., Jacques, D. and Madeleine, D.M. (2021) Conserva-tive Management of Uterine Adenomyosis: Medical vs. Surgical Approach. Journal of Clinical Medicine, 10, 4878-4878. [Google Scholar] [CrossRef] [PubMed] | | [6] | Upson, K. and Missmer, S.A. (2020) Epidemiology of Adenomyosis. Seminars in Reproductive Medicine, 38, 89-107. [Google Scholar] [CrossRef] [PubMed] | | [7] | Li, N., Yuan, M., Li, Q., et al. (2022) Higher Risk of Anxiety and Depression in Women with Adenomyosis as Compared with Those with Uterine Leiomyoma. Journal of Clinical Medi-cine, 11, 2638. [Google Scholar] [CrossRef] [PubMed] | | [8] | Zhang, H.Y., Wang, A.Q., Zhu, S., et al. (2022) Changes of Coagula-tion Function in Patients with Adenomyosis. Chinese Journal of Obstetrics and Gynecology, 57, 179-189. | | [9] | Indrielle-Kelly, T., Frühauf, F., Burgetová, A., et al. (2019) Diagnosis of Endometriosis 2nd Part—Ultrasound Diagnosis of Endometriosis (Adenomyosis, Endometriomas, Adhesions) in the Community. Czech Gynaecology, 84, 260-268. | | [10] | Brosens, I., Pijnenborg, R. and Benagiano, G. (2013) Defective Myometrial Spiral Ar-tery Remodelling as a Cause of Major Obstetrical Syndromes in Endometriosis and Adenomyosis. Placenta, 34, 100-105. [Google Scholar] [CrossRef] [PubMed] | | [11] | García-Solares, J., et al. (2018) Pathogenesis of Uterine Ade-nomyosis: Invagination or Metaplasia? Fertility and Sterility, 109, 371-379. [Google Scholar] [CrossRef] [PubMed] | | [12] | Hiraoka, T., Hirota, Y., Aikawa, S., et al. (2022) Constant Ac-tivation of STAT3 Contributes to the Development of Adenomyosis in Females. Endocrinology, 163, bqac044. [Google Scholar] [CrossRef] [PubMed] | | [13] | Zhai, J., Vannuccini, S., Petraglia, F. and Giudice, L.C. (2020) Ade-nomyosis: Mechanisms and Pathogenesis. Seminars in Reproductive Medicine, 38, 129-143. [Google Scholar] [CrossRef] [PubMed] | | [14] | Guo, S.W. (2020) The Pathogenesis of Adenomyosis vis-a-vis En-dometriosis. Journal of Clinical Medicine, 9, 485. [Google Scholar] [CrossRef] [PubMed] | | [15] | 黎霓, 王国云. 子宫腺肌病发病机制的研究现状[J]. 中国实用妇科与产科杂志, 2019, 35(5): 493-498. | | [16] | Meredith, S.M., Sanchez-Ramos, L. and Kaunitz, A.M. (2009) Diagnostic Accuracy of Transvaginal Sonography for the Diagnosis of Adenomyosis: Systematic Review and Metaanalysis. The American Journal of Obstetrics and Gynecology, 201, 107.e1-107.e 6. [Google Scholar] [CrossRef] [PubMed] | | [17] | Caridi, T.M., De la Garza-Ramos, C., Brook, O.R., et al. (2022) Uterine Artery Embolization for Symptomatic Adenomyosis: Proceedings from a Society of Interventional Radiology Foundation Research Consensus Panel. Journal of Vascular and Interventional Radiology, 33, 586-592. [Google Scholar] [CrossRef] [PubMed] | | [18] | Bazot, M. and Darai, E. (2018) Role of Transvaginal Sonography and Magnetic Resonance Imaging in the Diagnosis of Uterine Adenomyosis. Fertility and Sterility, 109, 389-397. [Google Scholar] [CrossRef] [PubMed] | | [19] | Reinhold, C., McCarthy, S., Bret, P.M., et al. (1996) Diffuse Adenomyosis: Comparison of Endovaginal US and MR Imaging with Histopathologic Correlation. Radiology, 199, 151-158. [Google Scholar] [CrossRef] [PubMed] | | [20] | 尹强, 费凡, 靳金岩, 曹艳婷. 子宫腺肌病和子宫肌瘤鉴别诊断中MRI检查的应用与效果评估[J]. 实用妇科内分泌电子杂志, 2021, 8(13): 138-140. | | [21] | 薛建秀. 子宫腺肌病MRI表现及诊断价值分析[J]. 影像研究与医学应用, 2020, 4(16): 181-182. | | [22] | van der Kooij, S.M., Hehenkamp, W.J.K., Birnie, E., et al. (2013) The Effect of Treatment Preference and Treatment Allocation on Patients’ Health-Related Quality of Life in the Randomized EMMY Trial. The European Journal of Obstetrics & Gynecology and Reproductive Biology, 169, 69-74. [Google Scholar] [CrossRef] [PubMed] | | [23] | Streuli, I., Dubuisson, J., Santulli, P., et al. (2014) An Update on the Pharmacological Management of Adenomyosis. Expert Opinion on Pharma-cotherapy, 15, 2347-2360. [Google Scholar] [CrossRef] [PubMed] | | [24] | 杨丽, 肖雁冰, 韩磊. 以保留子宫为目标的子宫腺肌病治疗研究进展[J]. 局解手术学杂志, 2020, 29(12): 1019-1023. | | [25] | Abbott, J.A. (2017) Adenomyosis and Abnormal Uterine Bleeding (AUB-A)-Pathogenesis, Diagnosis, and Management. Best Practice & Research Clinical Obstetrics & Gynaecology, 40, 68-81. [Google Scholar] [CrossRef] [PubMed] | | [26] | Dessouky, R., Gamil, S.A., Nada, M.G., Mousa, R. and Libda, Y. (2019) Management of Uterine Adenomyosis: Current Trends and Uterine Artery Embolization as a Potential Alterna-tive to Hysterectomy. Insights Imaging, 10, 48. [Google Scholar] [CrossRef] [PubMed] | | [27] | Chapron, C., Vannuccini, S., Santulli, P., et al. (2020) Diagnosing Adenomyosis: An Integrated Clinical and Imaging Approach. Human Reproduction Update, 26, 392-411. [Google Scholar] [CrossRef] [PubMed] | | [28] | Grimbizis, G.F., Mikos, T. and Tarlatzis, B. (2014) Uterus-Sparing Operative Treatment for Adenomyosis. Fertility and Sterility, 101, 472-487. [Google Scholar] [CrossRef] [PubMed] | | [29] | Osada, H. (2018) Uterine Adenomyosis and Adenomyoma: The Surgical Approach. Fertility and Sterility, 109, 406-417. [Google Scholar] [CrossRef] [PubMed] | | [30] | Liu, X., Ding, D., Ren, Y. and Guo, S.W. (2018) Transvaginal Elastosonography as an Imaging Technique for Diagnosing Adenomyosis. Reproductive Sciences, 25, 498-514. [Google Scholar] [CrossRef] [PubMed] | | [31] | Squillace, A.L.A., Simonian, D.S., Allegro, M.C., et al. (2021) Adenomyosis and in Vitro Fertilization Impacts—A Literature Review. Jornal Brasileiro de Reproducao Assistida, 25, 303-309. [Google Scholar] [CrossRef] [PubMed] | | [32] | Vannuccini, S., Luisi, S., Tosti, C., et al. (2018) Role of Medical Therapy in the Management of Uterine Adenomyosis. Fertility and Sterility, 109, 398-405. [Google Scholar] [CrossRef] [PubMed] | | [33] | Pontis, A., D’Alterio, M.N., Pirarba, S., et al. (2016) Adeno-myosis: A Systematic Review of Medical Treatment. Gynecological Endocrinology, 32, 696-700. [Google Scholar] [CrossRef] [PubMed] | | [34] | Kuan-HaoTsui, W.-L., Chen, C.-Y., Sheu, B.-C., et al. (2014) Medical Treatment for Adenomyosis and/or Adenomyoma. Taiwanese Journal of Obstetrics and Gynecology, 53, 459-465. [Google Scholar] [CrossRef] [PubMed] | | [35] | Harada, T. and Taniguchi, F. (2010) Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis. Women’s Health, 6, 27-35. [Google Scholar] [CrossRef] | | [36] | 彭超, 周应芳. 子宫腺肌病药物治疗选择及长期管理[J]. 中国实用妇科与产科杂志, 2019, 35(5): 516-519. |

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