Endometriose und Karzinogenese

Zusammenfassung Endometriose ist eine Erkrankung hoch komplexer Pathologie. Charakteristisch sind Infertilität und chronische Schmerzzustände. Darüber hinaus besteht ein 2‑ bis 4‑fach erhöhtes Risiko zur Entwicklung eines Ovarialkarzinoms. Die Molekularpathologie kennt inzwischen somatische Gen-Alterationen, die potenziell zu Endometriose und auch zu einer malignen Transformation führen können. Genomische Alterationen liegen nahe, sind aber zum jetzigen Zeitpunkt noch eher spekulativ. Abstract Endometriosis is a disease with a highly complex pathology. Characteristic features are infertility, chronic pain and a 2–4-fold increased risk of ovarian cancer. The molecular pathology now recognizes somatic gene alterations that can potentially lead to endometriosis and also to a malignant transformation. Genomic alterations are suspected but currently are still speculative. 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Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Additional information Redaktion Ricardo Felberbaum, Kempten Katharina Hancke, Ulm Wolfgang Janni, Ulm Wolfgang Küpker, Baden-Baden Hinweis des Verlags Der Verlag bleibt in Hinblick auf geografische Zuordnungen und Gebietsbezeichnungen in veröffentlichten Karten und Institutsadressen neutral. QR-Code scannen & Beitrag online lesen Rights and permissions About this article Cite this article Küpker, W., Felberbaum, R.E., Bullerdiek, J. et al. Endometriose und Karzinogenese. Gynäkologische Endokrinologie 24, 112–117 (2026). https://doi.org/10.1007/s10304-026-00685-x Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10304-026-00685-x