Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

Daniela M Dinulescu, Tan A Ince, Bradley J Quade, Sarah A Shafer, Denise Crowley, Tyler Jacks
Nature medicine · 2004 · vol. 11(1) , pp. 63–70 · doi:10.1038/nm1173 · PMID:15619626 · W2062495971
article OA: closed CC0 ⤵ 203 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Activation of oncogenic K-ras in mice, alone or with Pten deletion, induces peritoneal endometriosis and invasive, metastatic endometrioid ovarian adenocarcinomas.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The study developed genetic mouse models of peritoneal endometriosis and endometrioid ovarian adenocarcinoma driven by activation of an oncogenic K-ras allele, aiming to clarify mechanisms linking endometriosis and endometrioid ovarian cancer. In addition to showing that oncogenic K-ras expression or conditional Pten deletion in the ovarian surface epithelium induces preneoplastic ovarian lesions with endometrioid glandular morphology, the authors report that combining both mutations in the ovary produces invasive, widely metastatic endometrioid ovarian adenocarcinomas with complete penetrance and a latency of about 7 weeks, recapitulating key histomorphology and metastasis features of the human disease. A major limitation explicitly noted in the framing is that these are the first genetic models based on specific driver alterations, so the causal scope is tied to these engineered genotypes. This paper is centrally about endometriosis — it presents genetic mouse models of peritoneal endometriosis and shows how K-ras and Pten cooperate to drive endometrioid ovarian cancer.

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Condition tags

endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Ovarian Neoplasms Protein Tyrosine Phosphatases ras Proteins Tumor Suppressor Proteins Animals Endometriosis Endometriosis Endometriosis Female Mice Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Protein Tyrosine Phosphatases Protein Tyrosine Phosphatases PTEN Phosphohydrolase ras Proteins ras Proteins

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