Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study

Thomas M D'Hooghe, Thomas D’Hooghe, Thomas D'Hooghe, Olga Grechukhina, SiHyun Cho, Amelie Fassbender, O Dorien, Dorien O, Daniëlle Peterse, Joanne Weidhaas, Joanne B. Weidhaas, Hugh S Taylor
Gynecologic and obstetric investigation · 2019 · vol. 84(6) , pp. 575–582 · doi:10.1159/000500626 · PMID:31185482 · W2953083374
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This large European case-control study found no association between the KRAS 3' UTR rs61764370 polymorphism and endometriosis in infertile Caucasian women.

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Abstract

BACKGROUND: Endometriosis is a common disorder that affects 6-10% of reproductive age women. In a previous study, we demonstrated that a polymorphism in let-7 microRNA-binding site in the 3' untranslated region of the KRAS gene was found in 31% of subjects with endometriosis resistant to medical therapy. This polymorphism was now tested in a large, case-control study. METHODS: Peripheral blood or peritoneal biopsies from 2,077 European subjects with or without endometriosis and known infertility were tested for the presence of the variant allele using polymerase chain reaction. RESULTS: Histologically proven endometriosis was found in 1,140 subjects, while 937 subjects were disease free. Variant allele carrier rates in subjects with and without endometriosis were 15.7 and 15.1%, respectively. No association between the variant KRAS allele and stage of the disease, age at surgery, body mass index, or type of infertility was identified. CONCLUSION: A germ-line single-nucleotide polymorphism in the let-7 microRNA-binding site of the KRAS gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. However, it remains possible that this gene variant may be a marker of treatment resistance. Further studies on the role of this polymorphism in endometriosis are needed.

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Condition tags

endometriosisinfertility

MeSH descriptors

3' Untranslated Regions Endometriosis Polymorphism, Single Nucleotide Proto-Oncogene Proteins p21(ras) 3' Untranslated Regions Adult Binding Sites Binding Sites Case-Control Studies Endometriosis Europe Female Genetic Predisposition to Disease Genotype Humans Infertility, Female Infertility, Female MicroRNAs MicroRNAs Polymorphism, Single Nucleotide

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