Ovarian cancer-associated polymorphisms in the BNC2 gene among women with endometriosis

J Sundqvist, Jonas Sundqvist, H Falconer, Henrik Falconer, M Seddighzadeh, Maria Seddighzadeh, A Vodolazkaia, Alexandra Vodolazkaia, A Fassbender, Amelie Fassbender, C Kyama, Cleophas Kyama, A Bokor, Attila Bokor, Olof Stephansson, O Stephansson, Kristina Gemzell‐Danielsson, K Gemzell-Danielsson, Thomas D’Hooghe, T M D'Hooghe
Human Reproduction · 2011 · vol. 26(8) , pp. 2253–2257 · doi:10.1093/humrep/der169 · PMID:21642636 · W2117163822
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This study investigated six single nucleotide polymorphisms in the BNC2 gene in Caucasian women and found no association between these polymorphisms and endometriosis.

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Abstract

BACKGROUND: Endometriosis is a common benign gynaecological disease. Epidemiological studies have demonstrated associations between endometriosis and ovarian cancer. Recent genome-wide association studies of ovarian cancer have identified several single nucleotide polymorphisms (SNPs) in the Basonuclin 2 (BNC2) gene. In this study, we investigated these polymorphism in women with endometriosis. METHODS: Six SNPs in and upstream of the BNC2 gene (rs3814113, rs4445329, rs10962656, rs12379183, rs10756819 and rs1339552) were investigated using TaqMan allelic discrimination analysis in a Caucasian population (cases: 798, controls: 351). Allelic frequencies were used as main outcome measure. RESULTS: No associations were observed between the analysed SNPs and endometriosis. CONCLUSIONS: Our results suggest that the analysed polymorphisms in the BNC2 gene are unlikely to contribute to the previously reported risk of ovarian cancer in women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

DNA-Binding Proteins Endometriosis Ovarian Neoplasms Adult DNA-Binding Proteins Endometriosis Endometriosis Endometriosis Female Humans Ovarian Neoplasms Polymorphism, Single Nucleotide

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