Relationship between endometriosis and ovarian cancer.
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This study found that 4.5% of ovarian endometriosis cases developed ovarian cancer, with occurrence most strongly linked to patient age, sampling extent, and histologic report consistency.
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Abstract
PURPOSE: To investigate the occurrence of ovarian cancer (OC) arising in ovarian endometriosis (OE) diagnosed in our laboratory, and the relation of the disease to patient age. METHODS: Histopathological reports were reviewed in cases of endometriosis and ovarian cancer diagnosed between 1982 and 1989 and in 1997. The occurrence of OE and OC was studied in relation to patient age. RESULTS: Of the 796 OE cases, 36 (4.5%) ovarian cancers were found in the eight-year period, and of the 216 OC cases 36 (16.7%) were associated with OE; 12 patients (1.7%) were under 50 years old and 24 (22.9%) were over 50. In 1997 there were 168 cases of OE, and 4 cases were associated with OC. Of the 60 OC cases 4 cases arose in endometriosis. Two patients were over 50 and two under 50. CONCLUSION: In our report the occurrence of OC arising in OE was most influenced by patient age, the extent of sampling and the consistency of histologic reports about the presence of endometriosis in ovarian adenocarcinoma.
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Cited by (46)
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- The Association between Endometriomas and Ovarian Cancer: Preventive Effect of Inhibiting Ovulation and Menstruation during Reproductive Life 2015
- Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery 2015
- Endometriosis 2015
- Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas 2015
- Endometriosis‐Associated Ovarian Cancer 2014
- Peripheral Blood Telomere Content Is Greater in Patients With Endometriosis Than in Controls 2014
- Endometriosis and ovarian cancer 2013
- Extrapelvic endometriosis: a rare entity or an under diagnosed condition? 2013
- Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis 2013
- Etude phénotypique des cellules endométriosiques profondes 2012
- Endometrioza i proces nowotworowy 2012
- Migration of Cells from Experimental Endometriosis to the Uterine Endometrium 2012
- Pathophysiological factors and genetic association in endometriosis 2011
- Cinética celular na endometriose profunda infiltrativa de reto-sigmoide: estudo anátomo-clínico 2011
- Ovarian cancer-associated polymorphisms in the BNC2 gene among women with endometriosis 2011
- Clinicopathological characteristics of ovarian carcinomas associated with endometriosis 2011
- Endométriose et génétique : les gènes sont-ils responsables de la maladie ? 2010
- Risk of carcinoma in women with ovarian endometrioma 2010
- Endometriosis as a prognostic factor for cancer survival 2010
- Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis 2010
- The risk of malignancy in women with endometriosis 2010
- Endometriosis 2010
- Molecular profiling of human endometrium and endometriosis 2010
- Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer 2009
- Correlation of high-risk human papilloma viruses but not of herpes viruses or Chlamydia trachomatis with endometriosis lesions 2009
- An investigation of basic science and clinical research methodologies to benefit clinical practice 2009
- The relationship of endometriosis and ovarian malignancy: a review 2008
- Hibridação Genômica Comparativa em Endometriose 2008
- The risk of cancer and the role of parity among women with endometriosis 2007
- Endometriomas are more frequent on the left side 2007
- Endometriosis as a model for inflammation–hormone interactions in ovarian and breast cancers 2006
- Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical and epidemiological evidence 2006
- Molecular genetic evidence that endometriosis is a precursor of ovarian cancer 2006
- Endometriosis and the risk of cancer with special emphasis on ovarian cancer 2006
- Allelic loss studies do not provide evidence for the “endometriosis-as-tumor” theory 2005
- Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis 2005
- Endometriosis and the neoplastic process 2004
- Endometriosis and the risk of malignancy, especially ovarian cancer 2004
- Endometriosis and ovarian cancer: Thoughts on shared pathophysiology 2003
- Carcinome endométrioïde in situ et primitif de la trompe développé sur une endométriose tubo-ovarienne. À propos d'une observation 2003
- Ovarian and extraovarian endometriosis-associated cancer 2002
- Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis 2001
- Endometriosis-Associated Ovarian Carcinoma (EAOC): An Entity Distinct from Other Ovarian Carcinomas as Suggested by a Nested Case-Control Study 2001
- Diagnostic et suivi de l’endométriose en consultation : nouveautés 2001
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