Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis

Chou YC, Yu-Ching Chou, Chen YJ, Yi-Jen Chen, Yi‐Jen Chen, Chiung‐Ru Lai, Lai CR, Chiung-Ru Lai, Wang PH, Peng-Hui Wang, Peng‐Hui Wang, Hsin-Chan, Yuan CC, Chiou-Chung Yuan, Chiou‐Chung Yuan
European journal of obstetrics, gynecology, and reproductive biology · 2005 · vol. 124(1) , pp. 101–105 · doi:10.1016/j.ejogrb.2005.06.019 · PMID:16456945 · W2073226115
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This study found that cyclooxygenase-2 expression was elevated in ovarian cancer tissue adjacent to endometriosis compared to ovarian cancer without endometriosis.

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Abstract

ObjectivesThe purpose of this study was to examine if COX-2, CK7 and CK20 are involved in the malignant transformation of endometriosis.MethodsWe compared COX-2, CK7 and CK20 expressions between isolated endometriosis lesions and endometriosis lesions adjacent to ovarian carcinoma and between isolated ovarian carcinoma and ovarian carcinoma with implants of endometriosis. Immunoreactivity was quantified using an immunohistochemical scoring system that corresponds to an image analysis-based system.ResultsThere was no difference in COX-2, CK7 and CK20 expressions between the isolated endometriosis lesions and the endometriosis lesions adjacent to ovarian carcinoma. Similarly, CK7 and CK20 were equally expressed between the isolated ovarian carcinoma and the ovarian carcinoma with implants of endometriosis. The COX-2 over-expression rate was greater in ovarian carcinoma that was associated with endometriosis than in isolated ovarian carcinoma (27.8% versus 5.6%, P = 0.083). In endometrioid type ovarian carcinoma, the difference in COX-2 expression was statistically significant (50% versus 0%, P = 0.023).ConclusionsCOX-2 over-expression may be a result of the malignant transformation of endometriosis to endometrioid type ovarian cancer or may represent an interaction between the two cellular components. With respect to cytokeratins, neither CK7 nor CK20 appear to be involved in the malignant transformation of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Ovarian Neoplasms Ovarian Neoplasms Carcinoma, Endometrioid Carcinoma, Endometrioid Cyclooxygenase 2 Endometriosis Female Gene Expression Regulation, Neoplastic Humans Keratin-20 Keratin-7 Keratins Keratins Ovarian Neoplasms

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