Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types

Stern RC, R C Stern, Robert C. Stern, Dash R, Rajesh Dash, R Dash, Bentley RC, Rex C. Bentley, R C Bentley, M J Snyder, Snyder MJ, Matthew Snyder, A F Haney, Haney AF, Arthur F. Haney, Robboy SJ, S J Robboy, Stanley J. Robboy
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2001 · vol. 20(2) , pp. 133–139 · doi:10.1097/00004347-200104000-00004 · PMID:11293158 · W2106285116
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This study reviewed 1000 endometriosis cases, finding malignancy in 10.8% overall, with ovarian endometriosis more frequently associated with clear cell and endometrioid carcinomas, and extraovarian endometriosis with clear cell adenocarcinoma and adenosarcoma.

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This study reviewed one thousand consecutive cases of surgically proven endometriosis to determine the frequency and histological types of associated pelvic cancers. The researchers found that malignancy occurred in 10.8% of cases where they were the primary pathologists, compared to only 3.2% in previously diagnosed cases at the same institution. Clear cell and endometrioid carcinomas were the most common ovarian malignancies linked to endometriosis, while clear cell adenocarcinoma and adenosarcoma were predominant in extraovarian sites, with a significantly stronger association observed for endometrioid and clear cell tumors than for serous or mucinous types. Concurrent endometrial pathology was present in 32% of these malignant transformation cases. This paper is centrally about endometriosis — specifically analyzing the risk and histological characteristics of cancer arising within both ovarian and extraovarian endometriotic lesions.

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Abstract

One thousand consecutive cases of surgically proven endometriosis were reviewed to evaluate the frequency and types of pelvic cancers that were associated with ovarian and extraovarian endometriosis. The frequency and types of histologic abnormalities present in the eutopic endometrium when cancers were noted in endometriosis were also evaluated. In the large subset of cases for which the authors were the primary pathologists and all foci of endometriosis were recorded, the frequency of malignancy was 10.8%. In contrast, the frequency was only 3.2% in cases diagnosed by others previously in our institution. Cancers were more commonly found in ovaries when endometriosis was present in that ovary (5%) compared to when endometriosis was present at other sites (1%). Clear cell and endometrioid carcinomas were the malignancies most commonly seen in ovaries containing endometriosis, while clear cell adenocarcinoma and adenosarcoma were most commonly seen in conjunction with extraovarian endometriosis. The association of endometriosis with endometrioid and clear cell carcinoma was much stronger than that of serous and mucinous tumors (p < .01). Concurrent endometrial pathology was commonly seen in cases of malignant transformation of endometriosis (32% of cases).
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Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types - Robert C. Stern - Rajesh Dash - Rex C. Bentley - Matthew J. Snyder - Arthur F. Haney - Stanley J. Robboy Summary: One thousand consecutive cases of surgically proven endometriosis were reviewed to evaluate the frequency and types of pelvic cancers that were associated with ovarian and extraovarian endometriosis. The frequency and types of histologic abnormalities present in the eutopic endometrium when cancers were noted in endometriosis were also evaluated. In the large subset of cases for which the authors were the primary pathologists and all foci of endometriosis were recorded, the frequency of malignancy was 10.8%. In contrast, the frequency was only 3.2% in cases diagnosed by others previously in our institution. Cancers were more commonly found in ovaries when endometriosis was present in that ovary (5%) compared to when endometriosis was present at other sites (1%). Clear cell and endometrioid carcinomas were the malignancies most commonly seen in ovaries containing endometriosis, while clear cell adenocarcinoma and adenosarcoma were most commonly seen in conjunction with extraovarian endometriosis. The association of endometriosis with endometrioid and clear cell carcinoma was much stronger than that of serous and mucinous tumors (p < .01). Concurrent endometrial pathology was commonly seen in cases of malignant transformation of endometriosis (32% of cases).

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasms Neoplasms Ovarian Neoplasms Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenosarcoma Adenosarcoma Adenosarcoma Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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