FDG PET/CT in a Case of Clear Cell Carcinoma Arising From Abdominal Wall Endometriosis

He J, Jiani He, Aisheng Dong, Dong A, Xue Zhang, Zhang X
Clinical nuclear medicine · 2026 · vol. 51(10) , pp. 921–923 · doi:10.1097/rlu.0000000000006568 · PMID:42257570 · W7163908388
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

FDG PET/CT revealed intense uptake in a clear cell carcinoma arising from abdominal wall endometriosis and variable uptake in metastatic inguinal and pelvic lymph nodes.

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This case report describes the rare occurrence of clear cell carcinoma developing from abdominal wall endometriosis at a prior cesarean section scar. FDG PET/CT imaging revealed intense metabolic activity in the primary tumor with an SUVmax of 26, alongside variable uptake in multiple metastatic lymph nodes within the bilateral inguinal and pelvic regions. The authors note that malignant transformation of abdominal wall endometriosis is extremely uncommon but should be considered in the differential diagnosis for FDG-avid lesions located at abdominal incision sites. This paper is centrally about endometriosis — specifically the malignant transformation of abdominal wall endometriosis into clear cell carcinoma.

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Abstract

Abdominal wall endometriosis is rare. Malignant transformation of abdominal wall endometriosis is extremely rare. We describe FDG PET/CT findings in a case of clear cell carcinoma arising from abdominal wall endometriosis with multiple lymph node metastases. The primary tumor was located at the site of the prior cesarean section and showed intense FDG activity with a SUV max of 26. The metastatic lymph nodes in the bilateral inguinal and pelvic regions showed variable FDG-activity. This case indicates that malignant transformation of abdominal wall endometriosis should be included in the differential diagnosis of FDG-avid lesions in the abdominal incisional site.
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Interesting Images FDG PET/CT in a Case of Clear Cell Carcinoma Arising From Abdominal Wall Endometriosis - Jiani He* - Aisheng Dong† - Xue Zhang‡ Abdominal wall endometriosis is rare. Malignant transformation of abdominal wall endometriosis is extremely rare. We describe FDG PET/CT findings in a case of clear cell carcinoma arising from abdominal wall endometriosis with multiple lymph node metastases. The primary tumor was located at the site of the prior cesarean section and showed intense FDG activity with a SUVmax of 26. The metastatic lymph nodes in the bilateral inguinal and pelvic regions showed variable FDG-activity. This case indicates that malignant transformation of abdominal wall endometriosis should be included in the differential diagnosis of FDG-avid lesions in the abdominal incisional site. This case report describes an extremely rare cancer (clear cell carcinoma) that developed from abdominal wall endometriosis at a prior cesarean section scar. FDG PET/CT showed the primary tumor with intense FDG uptake and a SUVmax of 26, and multiple metastatic lymph nodes in the bilateral inguinal and pelvic regions with variable FDG activity. These imaging findings demonstrate that malignant transformation of abdominal wall endometriosis can present as FDG-avid lesions at abdominal incision sites. Clinicians and radiologists should consider this diagnosis when evaluating FDG-avid masses in surgical scars, especially in patients with a history of endometriosis. Text is machine generated and may contain inaccuracies. FAQ Copyright © 2026 Wolters Kluwer Health, LLC. All rights reserved.

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MeSH descriptors

Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Abdominal Wall Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell

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